Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse

NCT ID: NCT01749696

Last Updated: 2014-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

78 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-11-30

Study Completion Date

2014-04-30

Brief Summary

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The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).

Detailed Description

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The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus.

The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.

Conditions

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Pelvic Organ Prolapse

Study Groups

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Patients with pelvic organ prolapse

Patients, who were operated on because of pelvic organ prolapse.

No interventions assigned to this group

Patients without pelvic organ prolapse

Patients, who had hysterectomy due to other reasons than pelvic organ prolapse.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* surgery for pelvic organ prolapse
* hysterectomy due to other benign reasons than pelvic organ prolapse

Exclusion Criteria

* surgery due to malignancy
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Turku University Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Obstetrics and Gynecology, Turku University Central Hospital

Turku, , Finland

Site Status

Countries

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Finland

Other Identifiers

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33/180/2009

Identifier Type: -

Identifier Source: org_study_id

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