Investigator Initiated Clinical Study to Explore the Efficacy and Safety of Human Placenta Hydrolysate in the Chronic Fatigue Patients

NCT ID: NCT01742013

Last Updated: 2013-09-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2013-09-30

Brief Summary

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GCJBP Laennec Injection contains a variety of cytokines derived from human placenta, amino acids, peptides, nucleobases, and carbohydrates. This product is approved for improving liver function. Also, it has been prescribed for lots of diseases such as menopausal disorders, atopic dermatitis, skin cares as well as fatigue for long time. Although its action mechanism and clinical effectiveness are not still clear, there are reports which say a strong probability of its clinical effectiveness in the chronic fatigue patients.

This study aims to investigate the safety and efficacy of GCJBP Laennec Inj. (Human placenta hydrolysate) in the chronic fatigue patients through a randomized controlled tial.

Detailed Description

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Conditions

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Chronic Fatigue Syndrome Idiopathic Chronic Fatigue

Keywords

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Chronic Fatigue CFS ICF human placenta

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Placebo

NaCl 0.9%, s.c., 4ml (2ml x 2), 3 times per a week, 6 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Comparator

GCJBP Laennec Inj.

GCJBP Laennec Injection,s.c., 4ml(2ml x 2)/day, 3 times per a week, 6 weeks

Group Type EXPERIMENTAL

GCJBP Laennec Inj.

Intervention Type DRUG

Test drug

Interventions

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GCJBP Laennec Inj.

Test drug

Intervention Type DRUG

Placebo

Comparator

Intervention Type DRUG

Other Intervention Names

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Human placenta hydrolysate Normal saline solution (NaCl 0.9%)

Eligibility Criteria

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Inclusion Criteria

* Patient diagnosed with chronic fatigue syndrome or idiopathic chronic fatigue
* Given written informed consent
* Male or female aged between 20 and 65
* Patient who can read and answer to written questionnaires
* Patient who agrees to visit clinic for study drug injection 3 times per a week for 6 weeks

Exclusion Criteria

* Patient who has been administrated with any other investigational product for 28 days prior to screening visit
* Patient who is pregnant or childbearing potential female patient who does not consent for contraception during the study
* Patient who has a hypersensitivity provoked by study drug or others drived from animals
* Patient who has been received with any human placenta product for 6 months before study participation
* Abnormal liver function
* Abnormal renal function
* Back Depression Inventory (BDI) II is more than 29
* Underlying disease/conditions, in the investigator's judgment, which will be unable to participate in the study
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ajou University School of Medicine

OTHER

Sponsor Role collaborator

Green Cross Corporation

INDUSTRY

Sponsor Role collaborator

Symyoo

INDUSTRY

Sponsor Role collaborator

Ho Cheol Shin, M.D., Ph.D.

OTHER

Sponsor Role lead

Responsible Party

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Ho Cheol Shin, M.D., Ph.D.

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Ho Cheol Shin, M.D., Ph.d.

Role: PRINCIPAL_INVESTIGATOR

Kangbuk Samsung Hospital

Locations

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Kangbuk Samsung Hospital

Seoul, , South Korea

Site Status

Ajou University Hospital

Suwon, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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Laennec-IIT

Identifier Type: -

Identifier Source: org_study_id