The Clinical and Laboratory Phenotypes of Severe Asthma Patients in Clalit Health Services Haifa

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2014-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Asthma is a chronic illness characterized by inflammation of the airways. Severe asthma is defined in the literature as asthma not controlled by medication. In recent years it has become known that severe asthma is a variable disease and has subtypes relating to the age of onset, type of inflammation and allergy, obesity, etc.

Our aim is to characterize the phenotypes of severe asthma population in our clinic and compare the prevalent phenotypes to the phenotypes described before.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Study About the Identification of Treatable Traits of Severe Asthma and the Construction of Personalized Treatment System

NCT07136025

Asthma

RECRUITING NA

Longitudinal Observational Study of Severe Asthma

NCT01780142

Asthma

COMPLETED

Longitudinal Phenotyping and Endotyping Study in Adult Patients With Mild, Moderate, or Severe Asthma

NCT07189806

Asthma (Diagnosis)

RECRUITING

Treatable Traits of Severe Asthma

NCT06811740

Asthma

ENROLLING_BY_INVITATION NA

Identification of Asthma Phenotypes in Severe Asthmatics

NCT01623089

Asthma

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Study measures will include the following:

* asthma demographic and symptoms questionnaire
* Validation of proper inhaler technique
* Height, weight measurements
* Forced spirometry and reversibility testing
* DLCO
* Fractional excretion of NO in exhaled breath
* Chest and sinus CT
* Induced sputum analysis
* Complete blood count, electrolytes, immunoglobulin E, Aspergillus Specific IgE
* Skin allergy testing

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Asthma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Severe Asthma

Patients with severe asthma as specified under inclusion, exclusion criteria

Severe Asthma

Intervention Type OTHER

Demographic data, Spirometry, induced sputum, IgE, Aspergillus specific IgE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Severe Asthma

Demographic data, Spirometry, induced sputum, IgE, Aspergillus specific IgE

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Presence of Asthma- typical symptoms and signs accompanied by either: a. obstruction in Spirometry, OR- b. positive methacholine test
2. Regular use of high dose of inhaled corticosteroids (1000 micrograms of fluticasone per day or equivalent) in addition to a long acting beta agonist (LABA).
3. Lack of asthma control- 2 or more exacerbations in the past year- exacerbations defined by hospitalization or care in an emergency department or treatment with systemic glucocorticosteroids for exacerbation of asthma symptoms.