The Genetics Behind Vitamin D Status (VitDgen)

NCT ID: NCT01741233

Last Updated: 2013-08-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

102 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2013-03-31

Brief Summary

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The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status.

The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.

Detailed Description

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In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) .

Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.

Conditions

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Vitamin D Deficiency

Keywords

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SNPs vitamin D Vitamin D status UVB irradiation genetics

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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UV-B irraditation

VitDgen

Group Type EXPERIMENTAL

VitDgen

Intervention Type GENETIC

Interventions

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VitDgen

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Health participants over 18 years, that previously participated in VitmaD intervention study

Exclusion Criteria

* skindiseases
* intake of medicin that causes photosensitive skin
* pregnant or nursing
* sun vacation 3 month before the intervention
* intake of vitamin D supplement 3 month before the intervention
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bispebjerg Hospital

OTHER

Sponsor Role collaborator

Technical University of Denmark

OTHER

Sponsor Role lead

Responsible Party

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Lone Banke Rasmussen

M.Sc., Ph.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lone Rasmussen, M.Sc., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

DTU, Denmark

Locations

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Bispebjerg Hospital

Bispebjerg, Copenhagen, Denmark

Site Status

DTU / National Food Institute

Mørkhøj, Søborg, Denmark

Site Status

Countries

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Denmark

References

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Nissen J, Vogel U, Ravn-Haren G, Andersen EW, Madsen KH, Nexo BA, Andersen R, Mejborn H, Bjerrum PJ, Rasmussen LB, Wulf HC. Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D(3)-fortified bread and milk during winter in Denmark. Am J Clin Nutr. 2015 Jan;101(1):218-27. doi: 10.3945/ajcn.114.092148. Epub 2014 Nov 5.

Reference Type DERIVED
PMID: 25527766 (View on PubMed)

Other Identifiers

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H-4-2012-071

Identifier Type: -

Identifier Source: org_study_id