Bioequivalence Study For Orally-Disintegrating Tablet Of Sildenafil

NCT ID: NCT01737203

Last Updated: 2021-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

53 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2012-09-30

Brief Summary

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The purpose of this study is to assess the bioequivalence of Sildenafil ODT 50 mg without water to Japanese commercial oral tablet of sildenafil citrate (Viagra® tablet) 50 mg under fasted conditions.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Viagra

Oral tablet of sildenafil citrate (Japanese commercial tablet: Viagra® tablet) 50 mg as a single oral dose under fasted conditions

Group Type ACTIVE_COMPARATOR

Viagra

Intervention Type DRUG

50 mg tablet on Day 1 of each period

ODT without water

Sildenafil ODT 50 mg without water as a single oral dose under fasted conditions

Group Type EXPERIMENTAL

sildenafil ODT

Intervention Type DRUG

50 mg tablet on Day 1 of each period

ODT with water

Sildenafil ODT 50 mg with water as a single oral dose under fasted conditions

Group Type EXPERIMENTAL

sildenafil ODT

Intervention Type DRUG

50 mg tablet on Day 1 of each period

Interventions

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Viagra

50 mg tablet on Day 1 of each period

Intervention Type DRUG

sildenafil ODT

50 mg tablet on Day 1 of each period

Intervention Type DRUG

sildenafil ODT

50 mg tablet on Day 1 of each period

Intervention Type DRUG

Other Intervention Names

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sildenafil citrate

Eligibility Criteria

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Inclusion Criteria

* Healthy Japanese male subjects between the ages of 20 and 55 years.
* Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight \>50 kg (110 lbs).

Exclusion Criteria

* Baseline orthostatic hypotension defined as a \>=20 mm Hg reduction in systolic blood pressure (SBP), a \>=10 mm Hg reduction in diastolic blood pressure (DBP) or the development of significant postural symptoms (dizziness, lightheadedness, vertigo) when going from the supine to standing position.
* Subjects who are currently prescribed or taking nitrates or nitric oxide donors in any form on either a regular or intermittent basis.
Minimum Eligible Age

20 Years

Maximum Eligible Age

55 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Minato-ku, Tokyo, Japan

Site Status

Countries

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Japan

Related Links

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Other Identifiers

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A1481315

Identifier Type: -

Identifier Source: org_study_id

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