A Study Of The Safety and Efficacy Of Viagra In Men With Erectile Dysfunction Who Do Not Self Identify.

NCT ID: NCT00343200

Last Updated: 2021-02-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

371 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-07-31

Study Completion Date

2007-09-30

Brief Summary

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To compare the efficacy and safety of Viagra (sildenafil citrate) vs. placebo for the treatment of men with ED and at least 1 prespecified risk factor who do not self identify as having ED.

Detailed Description

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Conditions

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Impotence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo tablet orally approximately 1 hour before sexual activity, with no more than 1 dose in a 24-hour period, for a total of 8 weeks (DB phase). In 4-week OL phase, subjects received sildenafil 50 mg or 100mg orally approximately 1 hour before sexual activity, with no more than 1 dose in a 24-hour period.

Sildenafil

Group Type EXPERIMENTAL

Viagra (sildenafil citrate)

Intervention Type DRUG

Sildenafil 50 mg or 100mg orally approximately 1 hour before sexual activity, with no more than 1 dose in a 24-hour period, for a total of 12 weeks (8-week DB phase and 4-week OL phase).

Interventions

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Placebo

Placebo tablet orally approximately 1 hour before sexual activity, with no more than 1 dose in a 24-hour period, for a total of 8 weeks (DB phase). In 4-week OL phase, subjects received sildenafil 50 mg or 100mg orally approximately 1 hour before sexual activity, with no more than 1 dose in a 24-hour period.

Intervention Type DRUG

Viagra (sildenafil citrate)

Sildenafil 50 mg or 100mg orally approximately 1 hour before sexual activity, with no more than 1 dose in a 24-hour period, for a total of 12 weeks (8-week DB phase and 4-week OL phase).

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Men who do not identify as having ED with documented ED
* Men 30 years of age and older
* At least one prespecified risk factor for ED

Exclusion Criteria

* Subjects currently prescribed, taking and/or likely to be treated with nitrates or nitric oxide donors in any form on either a regular or intermittent basis
* Subjects with a known history of retinitis pigmentosa.
Minimum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Huntsville, Alabama, United States

Site Status

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Mesa, Arizona, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Anaheim, California, United States

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Beverly Hills, California, United States

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Huntington Beach, California, United States

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San Diego, California, United States

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Santa Rosa, California, United States

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Aurora, Colorado, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Avon, Connecticut, United States

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Manchester, Connecticut, United States

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Wilmington, Delaware, United States

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Washington D.C., District of Columbia, United States

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Hollywood, Florida, United States

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Jacksonville, Florida, United States

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Ocala, Florida, United States

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Pembroke Pines, Florida, United States

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Tampa, Florida, United States

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Peoria, Illinois, United States

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Fort Wayne, Indiana, United States

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Arkansas City, Kansas, United States

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Newton, Kansas, United States

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Overland Park, Kansas, United States

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Wichita, Kansas, United States

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Wichita, Kansas, United States

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Livonia, Michigan, United States

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Edina, Minnesota, United States

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Las Vegas, Nevada, United States

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Binghamton, New York, United States

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Endwell, New York, United States

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New York, New York, United States

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Cincinnati, Ohio, United States

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Mogadore, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Greer, South Carolina, United States

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Simpsonville, South Carolina, United States

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Nashville, Tennessee, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Salt Lake City, Utah, United States

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Richmond, Virginia, United States

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Spokane, Washington, United States

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Tacoma, Washington, United States

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Oregon, Wisconsin, United States

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Countries

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United States

References

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Cappelleri JC, Chambers R. Addressing Bias in Responder Analysis of Patient-Reported Outcomes. Ther Innov Regul Sci. 2021 Sep;55(5):989-1000. doi: 10.1007/s43441-021-00298-5. Epub 2021 May 27.

Reference Type DERIVED
PMID: 34046875 (View on PubMed)

Kaminetsky JC, Stecher V, Tseng LJ. Quality of erections by age group in men with erectile dysfunction. Int J Clin Pract. 2017 Oct;71(10). doi: 10.1111/ijcp.12976. Epub 2017 Sep 11.

Reference Type DERIVED
PMID: 28892218 (View on PubMed)

Shabsigh R, Kaufman J, Magee M, Creanga D, Russell D, Budhwani M. Lack of awareness of erectile dysfunction in many men with risk factors for erectile dysfunction. BMC Urol. 2010 Nov 5;10:18. doi: 10.1186/1471-2490-10-18.

Reference Type DERIVED
PMID: 21054874 (View on PubMed)

Related Links

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Other Identifiers

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A1481247

Identifier Type: -

Identifier Source: org_study_id

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