Renal Response to Lower Body Negative Pressure in Pre-hypertensive States
NCT ID: NCT01734096
Last Updated: 2017-05-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
78 participants
INTERVENTIONAL
2009-05-31
2016-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
QUADRUPLE
Study Groups
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control group
healthy volunteer
Lower body negative pressure (LBNP)
Lower limbs are put in in LBNP device for one hour (-30 mbar)
Candesartan cilexetil
candesartan cilexetil 16 mg once a day for 7 days cross over with placebo in control group, obesisty group and white coat hypertension group
obesity group
Patients with BMI \>30 Kg/m2
Lower body negative pressure (LBNP)
Lower limbs are put in in LBNP device for one hour (-30 mbar)
Candesartan cilexetil
candesartan cilexetil 16 mg once a day for 7 days cross over with placebo in control group, obesisty group and white coat hypertension group
white coat hypertension group
Patients with office blood pressure \>140/90 mmHg and ambulatory daytime blood pressure \<135/85 mmHg
Lower body negative pressure (LBNP)
Lower limbs are put in in LBNP device for one hour (-30 mbar)
Candesartan cilexetil
candesartan cilexetil 16 mg once a day for 7 days cross over with placebo in control group, obesisty group and white coat hypertension group
Resistant hypertension
Patients with ambulatory blood pressure \> 135/85 mm Hg (day) or \>120/70 mm Hg (night) with 3 antihypertensive drugs with direct observance of drug taking.
Lower body negative pressure (LBNP)
Lower limbs are put in in LBNP device for one hour (-30 mbar)
Interventions
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Lower body negative pressure (LBNP)
Lower limbs are put in in LBNP device for one hour (-30 mbar)
Candesartan cilexetil
candesartan cilexetil 16 mg once a day for 7 days cross over with placebo in control group, obesisty group and white coat hypertension group
Eligibility Criteria
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Inclusion Criteria
* office BP \>140/90 and daytime ambulatory blood pressure \<135/85 (white coat hypertension group) \_daytime abpm \>135/85 mm Hg or nighttime abpm 120/70
Exclusion Criteria
* Diabetes type 1 or type 2
* History of renal artery stenosis
* Acute illness
18 Years
65 Years
ALL
Yes
Sponsors
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Swiss National Science Foundation
OTHER
PD Dr. Grégoire Wuerzner
OTHER
Responsible Party
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PD Dr. Grégoire Wuerzner
Doctord, MD, privat docent
Principal Investigators
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Gregoire Wuerzner, MD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universitaire Vaudois
Michel Burnier, MD
Role: STUDY_CHAIR
Centre Hospitalier Universitaire Vaudois
Locations
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Service of nephrology and hypertension
Lausanne, Canton of Vaud, Switzerland
Service of nephrology and hypertension
Lausanne, , Switzerland
Countries
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References
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Vakilzadeh N, Petrovic D, Maillard M, Favre L, Grouzmann E, Wuerzner G. Impact of obesity with or without hypertension on systemic haemodynamic and renal responses to lower body negative pressure. Blood Press. 2021 Feb;30(1):67-74. doi: 10.1080/08037051.2020.1829963. Epub 2020 Oct 19.
Vuignier Y, Grouzmann E, Muller O, Vakilzadeh N, Faouzi M, Maillard MP, Qanadli SD, Burnier M, Wuerzner G. Blood Pressure and Renal Responses to Orthostatic Stress Before and After Radiofrequency Renal Denervation in Patients with Resistant Hypertension. Front Cardiovasc Med. 2018 May 23;5:42. doi: 10.3389/fcvm.2018.00042. eCollection 2018.
Other Identifiers
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PZ00P3_121655
Identifier Type: -
Identifier Source: org_study_id
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