A Study to Estimate the Occurrence of Rotavirus Gastroenteritis in Children < 5 Years of Age, in Bulgaria and Latvia

NCT ID: NCT01733849

Last Updated: 2017-01-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1266 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2014-06-30

Brief Summary

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This study aims to estimate the real situation of rotavirus gastroenteritis (RV GE) in the primary care settings of both Bulgaria and Latvia in children less than 5 years of age.

Detailed Description

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A Primary care setting will include independent general practitioners (GP) (specialised in paediatrics) or independent paediatricians.

Stool samples will be collected from all enrolled subjects at Visit 1 (Day 0) and tested immediately after collection. The stool sample will be stored for 24 hours only, in case the test cannot be performed immediately after collection.

Conditions

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Infections, Rotavirus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group Bulgaria

Subjects in this group include infants/children from Bulgaria, less than five years of age with home visits by the GP/paediatrician for the treatment of AGE or brought to the GP/paediatrician for the treatment of AGE.

Stool sample

Intervention Type OTHER

Samples will be tested to determine the presence or absence of rotavirus.

Data collection

Intervention Type OTHER

Log books

Group Latvia

Subjects in this group include infants/children from Latvia, less than five years of age with home visits by the GP/paediatrician for the treatment of AGE or brought to the GP/paediatrician for the treatment of AGE.

Stool sample

Intervention Type OTHER

Samples will be tested to determine the presence or absence of rotavirus.

Data collection

Intervention Type OTHER

Log books

Interventions

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Stool sample

Samples will be tested to determine the presence or absence of rotavirus.

Intervention Type OTHER

Data collection

Log books

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Infants/children with home visits by the GPGP/paediatrician for the treatment of AGE or brought to the GP/paediatrician for AGE treatment during the study period.
* A male or female infant/child less than five years of age at the time of the GP/paediatrician visit. A child becomes ineligible on the day of her/his fifth birthday.
* Written informed consent obtained from the parents/legally acceptable representative (LARs) of the subject.
* Subjects who the investigator believes that his/her, parents/LARs can and will comply with the requirements of the protocol.

Exclusion Criteria

• Child in care.
Maximum Eligible Age

5 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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GSK Investigational Site

Burgas, , Bulgaria

Site Status

GSK Investigational Site

Burgas, , Bulgaria

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GSK Investigational Site

Dobrich, , Bulgaria

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Pazardzhik, , Bulgaria

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Pleven, , Bulgaria

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Plovdiv, , Bulgaria

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Rousse, , Bulgaria

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Sliven, , Bulgaria

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Sofia, , Bulgaria

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Sofia, , Bulgaria

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Sofia, , Bulgaria

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Sofia, , Bulgaria

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Stara Zagora, , Bulgaria

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Varna, , Bulgaria

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Veliko Tarnovo, , Bulgaria

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Balvi, , Latvia

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Bauska, , Latvia

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Brocēni, , Latvia

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Carnikava, , Latvia

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Daugavpils, , Latvia

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Daugavpils, , Latvia

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Druva, , Latvia

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Erglu Pagasts, , Latvia

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Grobiņa, , Latvia

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Ikšķile, , Latvia

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Jelgava, , Latvia

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Jelgava, , Latvia

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Jelgava, , Latvia

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Jelgava, , Latvia

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Jēkabpils, , Latvia

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Kuldīga, , Latvia

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Liepāja, , Latvia

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Limbaži, , Latvia

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Līvāni, , Latvia

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Madona, , Latvia

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Ogre, , Latvia

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Ozolnieki, , Latvia

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Piņķi, , Latvia

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Rēzekne, , Latvia

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Rēzekne, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Riga, , Latvia

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Ropaži, , Latvia

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Sigulda, , Latvia

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Tukums, , Latvia

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Valmiera, , Latvia

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Valmiera, , Latvia

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Vangaži, , Latvia

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Ventspils, , Latvia

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GSK Investigational Site

Ventspils, , Latvia

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Countries

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Bulgaria Latvia

References

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Tafalla M, Gardovska D, Gopala K, Kozlovska L. Primary care-based surveillance to estimate the proportion of rotavirus gastroenteritis among Latvian children below 5 years of age with acute gastroenteritis. Hum Vaccin Immunother. 2019;15(6):1272-1278. doi: 10.1080/21645515.2018.1534515. Epub 2018 Oct 31.

Reference Type DERIVED
PMID: 30335570 (View on PubMed)

Tiholova M, Gopala K, Berberova M, Strokova-Stoilova M, Tafalla M. Rotavirus gastroenteritis in children less than five years of age in primary care settings in Bulgaria: an observational study. Germs. 2016 Sep 1;6(3):97-105. doi: 10.11599/germs.2016.1095. eCollection 2016 Sep.

Reference Type DERIVED
PMID: 27622162 (View on PubMed)

Other Identifiers

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116621

Identifier Type: -

Identifier Source: org_study_id

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