Reducing and Removing Hyaluronic Acid Filler With Hyaluronidase

NCT ID: NCT01722916

Last Updated: 2025-01-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

EARLY_PHASE1

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Study Completion Date

2025-12-31

Brief Summary

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The purpose of this study is to find how much hyaluronidase should be used when receiving injections of fillers.

Detailed Description

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Conditions

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Drug Safety

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Dose of Hyaluronidase

Group Type EXPERIMENTAL

Hyaluronidase

Intervention Type DRUG

Interventions

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Hyaluronidase

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age 18 and over
* The subjects are in good health
* The subject has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator

Exclusion Criteria

* Under 18 years of age
* Pregnancy or Lactation
* Subjects who are unable to understand the protocol or to give informed consent
* Subjects with mental illness
* Recent Accutane use in the past 6 months
* Subjects prone to hypertrophic and keloidal scarring
* Subjects with tattoos and/or scars on upper medial arms (the treatment area)
* Subjects with known hypersensitivity to hyaluronic acid
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Northwestern University

OTHER

Sponsor Role lead

Responsible Party

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Murad Alam

Professor in Dermatology, Otolaryngology- Head and Neck Surgery and Surgery-Organ Transplantation

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Murad Alam, MD

Role: PRINCIPAL_INVESTIGATOR

Northwestern University

Locations

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Northwestern University Department of Dermatology

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Alam M, Hughart R, Geisler A, Paghdal K, Maisel A, Weil A, West DP, Veledar E, Poon E. Effectiveness of Low Doses of Hyaluronidase to Remove Hyaluronic Acid Filler Nodules: A Randomized Clinical Trial. JAMA Dermatol. 2018 Jul 1;154(7):765-772. doi: 10.1001/jamadermatol.2018.0515.

Reference Type DERIVED
PMID: 29710212 (View on PubMed)

Other Identifiers

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STU68166

Identifier Type: -

Identifier Source: org_study_id

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