An Evaluation of an Injectable Material for Correction of Wrinkles

NCT ID: NCT00510081

Last Updated: 2014-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE3

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2009-02-28

Brief Summary

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The objective of this study is to determine the effectiveness of a filler in improving wrinkles.

Detailed Description

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The primary objective of this study is to determine whether focal injection of calcium hydroxylapatite (Radiesse®), an injectable biodegradable filler, into jowl-induced chin notches can result in safe, aesthetically pleasing, and long-lasting correction of these.

Conditions

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Jowls

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

subjects will receive filler injections

Group Type EXPERIMENTAL

Calcium Hydroxylapatite injection

Intervention Type DEVICE

filler injection

Interventions

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Calcium Hydroxylapatite injection

filler injection

Intervention Type DEVICE

Other Intervention Names

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Radiesse

Eligibility Criteria

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Inclusion Criteria

* Age 40-65
* Have wrinkles
* The subjects are in good health.
* The subject has willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator.

Exclusion Criteria

* Subjects who have received within the past 3 months or are planning to receive in the next 6 months, botulinum toxin injections for correction of wrinkles.
* Subjects who have received within the past one year any soft tissue augmentation material into the chin and experimental area (defined as any area on the face below the lower lip vermilion, excluding the lateral lip marionette line up to 1 cm below this level).
* Subjects with prior history of nodule formation or hypersensitivity reactions to lidocaine or medium-term augmentation materials, including hyaluronic acid derivatives, poly-L-lactic acid, and calcium hydroxylapatite.
* Subjects who are currently using anticoagulation therapy.
* Subjects who have a history of bleeding disorders.
* Subjects who are unable to understand the protocol or to give informed consent.
* Subjects with mental illness.
Minimum Eligible Age

40 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Northwestern University

OTHER

Sponsor Role lead

Responsible Party

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Northwestern University

Principal Investigators

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Murad Alam, MD

Role: PRINCIPAL_INVESTIGATOR

Northwestern University, Feinberg School of Medicine, Department of Dermatology

Countries

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United States

Other Identifiers

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1253-013

Identifier Type: -

Identifier Source: org_study_id