Prospective Cohort Study for Analyzing the Effect of Gastric Cancer Surgery to the Metabolic Syndrome and Insulin Resistance
NCT ID: NCT01714622
Last Updated: 2019-03-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
OBSERVATIONAL
2012-10-31
2016-10-31
Brief Summary
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Although the definition of metabolic syndrome is various, but it is normally accepted as a state that insulin resistance or glucose intolerance combined with hypertension or hyperlipidemia or obesity. Metabolic syndrome is a worldwide health problem, and the treatment is modification of life style, weight loss and medication. However, in most of the patients metabolic syndrome is considered not curable disease. Recent studies have shown that some bariatric surgery offers not only control the overweight but also metabolic syndrome. The exact mechanism is still unknown but decreased gastric volume and intestinal bypass itself seemed to play an important role to improve metabolic syndrome over just decreased weight.
For treating gastric cancer, gastrectomy is essential and the extent of gastrectomy is varied subtotal and total gastrectomy according to the location of tumor. Also, reconstruction type is varied gastroduodenostomy and Roux-en-Y gastrojejunostomy after subtotal gastrectomy, esophagojejunostomy after total gastrectomy. This kind of operation for gastric cancer lead decreased gastric volume and/or intestinal bypass, which means this operation could lead similar effect of bariatric surgery. Already, there have been several retrospective reports that metabolic syndrome or diabetes was improved after gastrectomy for gastric cancer but no prospective study about this subject yet in Korea.
The purpose of this study is that evaluating the degree of improvement of metabolic syndrome after gastrectomy for gastric cancer, and analyze the differences between the type of operation.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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metabolic syndrome
gastric cancer patients with metabolic syndrome
subtotal gastrectomy with gastroduodenostomy
subtotal gastrectomy with Roux-en-Y gastrojejunostomy,
total gastrectomy with Rou-en-Y esophagojejunostomy
metabolic disease
gastric cancer patients with metabolic disease
subtotal gastrectomy with gastroduodenostomy
subtotal gastrectomy with Roux-en-Y gastrojejunostomy,
total gastrectomy with Rou-en-Y esophagojejunostomy
normal
gastric cancer patients without metabolic syndrome or metabolic disease
subtotal gastrectomy with gastroduodenostomy
subtotal gastrectomy with Roux-en-Y gastrojejunostomy,
total gastrectomy with Rou-en-Y esophagojejunostomy
Interventions
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subtotal gastrectomy with gastroduodenostomy
subtotal gastrectomy with Roux-en-Y gastrojejunostomy,
total gastrectomy with Rou-en-Y esophagojejunostomy
Eligibility Criteria
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Inclusion Criteria
2. in plan for gastrectomy for gastric cancer
3. ages between 20 to 85 years old
4. assign in consent
Exclusion Criteria
2. had low performance scale due to severe cardiovascular disease.
20 Years
80 Years
ALL
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Locations
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Department of Surgery, Yonsei University Colleage of Medicine,
Seoul, , South Korea
Ji Yeong An
Seoul, , South Korea
Sevrance hospital, Department of General surgery
Seoul, , South Korea
Countries
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Other Identifiers
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4-2012-0550
Identifier Type: -
Identifier Source: org_study_id
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