Monitoring of Hemodynamics in Heart Failure Patients by Intracardiac Impedance Measurement

NCT ID: NCT01711281

Last Updated: 2015-07-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-10-31

Brief Summary

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Heart Failure (HF) is one of the most frequent diagnoses upon hospitalization and is a major cause of death. Cardiac resynchronization therapy (CRT) using an implantable device for synchronous bi-ventricular stimulation leads to improvement of hemodynamic parameters, physical capacity and quality of life. A continuous measurement of the left-ventricular volume would provide information about heart performance and could be used for both heart failure monitoring and optimization of CRT-therapy.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Intracardiac Impedance Measurement

Group Type EXPERIMENTAL

Intracardiac Impedance Measurement Algorithm (integrated in CRT-D device)

Intervention Type DEVICE

Interventions

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Intracardiac Impedance Measurement Algorithm (integrated in CRT-D device)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* De novo CRT-patients
* Planned implantation with a Lumax 740 HF-T device, a bipolar LV-lead and a true bipolar RV-lead
* NYHA class II or III
* QRS ≥ 150 ms
* LVEF between 15% and 35%
* LVEDD ≥ 55 mm
* Evaluable echo measurements

Exclusion Criteria

* Persistent or permanent atrial fibrillation
* Heart surgery within the previous 3 months or planned for the time of study participation; post-heart transplantation or listed for heart transplantation
* Non-ambulatory patients
* Chronic renal dialysis
* Life expectancy less than 1 year due to a non-cardiac disease
* Age \< 18 years and/or limited contractual capability
* Addiction to alcohol, medical drugs or illegal drugs
* Pregnant or breast-feeding women
* Participation in another clinical trial
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biotronik SE & Co. KG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Peter Sogaard, MD, PhD, Prof.

Role: STUDY_CHAIR

Aalborg University, Aalborg University Hospital

Klaus-Jürgen Gutleben, MD, PhD

Role: STUDY_CHAIR

Herz- und Diabeteszentrum NRW, Bad Oeynhausen

Locations

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Aalborg Sygehus, Kardiologisk Afdeling

Aalborg, , Denmark

Site Status

Aarhus Universitetshospital, Hjertemedicinsk Afdeling B

Aarhus, , Denmark

Site Status

Gentofte Hospital, Department P

Hellerup, , Denmark

Site Status

Odense University Hospital, Hjertemedicinsk Afdeling B

Odense, , Denmark

Site Status

Herz- und Diabeteszentrum NRW

Bad Oeynhausen, , Germany

Site Status

Charité Campus Virchow-Klinik, Medizinische Klinik mit Schwerpunkt Kardiologie

Berlin, , Germany

Site Status

Herzzentrum Brandenburg, Immanuel Klinikum

Bernau, , Germany

Site Status

Klinikum Bielefeld Mitte

Bielefeld, , Germany

Site Status

Evangelisches Krankenhaus

Bielefeld, , Germany

Site Status

Universitätsklinikum Essen, Westdeutsches Herzzentrum Essen

Essen, , Germany

Site Status

Medizinische Hochschule Hannover, Klinik für Kardiologie und Angiologie

Hanover, , Germany

Site Status

Kliniken Maria Hilf GmbH, Innere Medizin II, Klinik für Kardiologie

Mönchengladbach, , Germany

Site Status

Klinikum der Universität München - Grosshadern

München, , Germany

Site Status

Havellandklinik Nauen

Nauen, , Germany

Site Status

Krankenhaus Reinbek St. Adolf-Stift, Innere Abt. Kardiologie

Reinbek, , Germany

Site Status

Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik I, Medizinische Intensiv- und Notfallmedizin

Würzburg, , Germany

Site Status

Azienda Ospedaliero Univesitaria, Ospedali Riuniti Umberto I- G.M. Lancisi- G. Salesi

Ancona, , Italy

Site Status

Fondazione Toscana G. Monasterio

Pisa, , Italy

Site Status

Leiden University Medical Center

Leiden, , Netherlands

Site Status

Erasmus Medical Center

Rotterdam, , Netherlands

Site Status

Isala Klinieken, Hospital de Weezenlanden, Department of Cardiology

Zwolle, , Netherlands

Site Status

Universitätsspital Zürich

Zurich, , Switzerland

Site Status

Countries

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Denmark Germany Italy Netherlands Switzerland

Other Identifiers

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CR010

Identifier Type: -

Identifier Source: org_study_id

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