C11-Acetate PET/CT in Multiple Myeloma: Added Value to F18-Fluorodeoxyglucose PET/CT

NCT ID: NCT01691300

Last Updated: 2015-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2015-11-30

Brief Summary

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Positron emission tomography combined with computed tomography using carbon-11 acetate (ACT PET/CT) may help detect lesions before treatment and evaluate response following therapy in patients with from multiple myeloma (MM). This study aimed to prospectively assess the clinical utility of ACT PET/CT in MM as compared to the commonly used F18-fluorodeoxyglucose(FDG).

Detailed Description

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Conditions

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Multiple Myeloma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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ACT PET/CT

Dual-tracer ACT/FDG PET/CT and WB-DCE-MRI at baseline (pretreatment), post-induction and post-ASCT (if eligible)

Group Type EXPERIMENTAL

ACT PET/CT

Intervention Type OTHER

Old tracer but new indication

Interventions

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ACT PET/CT

Old tracer but new indication

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* at least 20 years of age
* previously untreated
* complete pre-treatment clinical staging including bone marrow examination
* written informed consent to participate in the study

Exclusion Criteria

* concurrent active malignant tumor(s)
* pregnant or breast feeding women
* non-compliant to PET/CT or to MRI
* marked renal impairment (contraindicated for contrast-enhanced MRI)
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Chieh Lin, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Molecular Imaging Center and Nuclear Medicine, Chang Gung Memorial Hospital

Locations

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Chang Gung Memorial Hostpial

Guishan, Taoyuan County, Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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99-2177A

Identifier Type: -

Identifier Source: org_study_id

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