Regulation of Tissue Lipolysis by Insulin in Type 2 Diabetes
NCT ID: NCT01680133
Last Updated: 2012-10-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
20 participants
OBSERVATIONAL
2007-06-30
2011-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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NGT
Normal glycaemic healthy control men, age between 45-65, BMI 25-35 kg/m2
Hyperinsulinemic euglycemic clamp
T2D
Type 2 diabetic men, age 45-65 yrs, BMI 25-35, diagnosed \>5yrs and Hba1c 7-9%
Hyperinsulinemic euglycemic clamp
Interventions
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Hyperinsulinemic euglycemic clamp
Eligibility Criteria
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Inclusion Criteria
* Normal blood pressure (SBP 100-140 mmHg, DBP 60-90 mmHg)
* weight stable in last 3 months
Exclusion Criteria
* people with intensive fitness training (e.g. athletes \> 3 times/week)
* History of cardiovascular diseases
* Bleeding disorders
* Use of medication interfering with the study endpoints/hypotheses (e.g. beta-blockers)
* Not to be able to understand the study information
* Subjects on a special diet or vegetarian
* Blood donation 2 months prior to the study and during the study
* Participating in an other study
45 Years
65 Years
MALE
Yes
Sponsors
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Netherlands Organisation for Scientific Research
OTHER_GOV
European Foundation for the Study of Diabetes
OTHER
Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Ellen Blaak, PhD
Role: PRINCIPAL_INVESTIGATOR
Maastricht University Medical centre
Locations
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Department of Human Biology, Maastricht University Medical Centre
Maastricht, , Netherlands
Countries
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References
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Jocken JW, Moro C, Goossens GH, Hansen D, Mairal A, Hesselink MK, Langin D, van Loon LJ, Blaak EE. Skeletal muscle lipase content and activity in obesity and type 2 diabetes. J Clin Endocrinol Metab. 2010 Dec;95(12):5449-53. doi: 10.1210/jc.2010-0776. Epub 2010 Sep 15.
Jocken JW, Roepstorff C, Goossens GH, van der Baan P, van Baak M, Saris WH, Kiens B, Blaak EE. Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. Diabetes. 2008 Jul;57(7):1834-41. doi: 10.2337/db07-0857. Epub 2008 Apr 8.
Jocken JW, Goossens GH, van Hees AM, Frayn KN, van Baak M, Stegen J, Pakbiers MT, Saris WH, Blaak EE. Effect of beta-adrenergic stimulation on whole-body and abdominal subcutaneous adipose tissue lipolysis in lean and obese men. Diabetologia. 2008 Feb;51(2):320-7. doi: 10.1007/s00125-007-0866-y. Epub 2007 Dec 5.
Boon H, Blaak EE, Saris WH, Keizer HA, Wagenmakers AJ, van Loon LJ. Substrate source utilisation in long-term diagnosed type 2 diabetes patients at rest, and during exercise and subsequent recovery. Diabetologia. 2007 Jan;50(1):103-12. doi: 10.1007/s00125-006-0482-2. Epub 2006 Nov 28.
Jocken JW, Goossens GH, Boon H, Mason RR, Essers Y, Havekes B, Watt MJ, van Loon LJ, Blaak EE. Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance. Diabetologia. 2013 Oct;56(10):2255-65. doi: 10.1007/s00125-013-2995-9. Epub 2013 Aug 2.
Other Identifiers
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91611074
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
07-3-037
Identifier Type: -
Identifier Source: org_study_id