Observational Study of Denosumab (Prolia®) in Postmenopausal Women With Osteoporosis

NCT ID: NCT01668589

Last Updated: 2018-01-30

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1501 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-28

Study Completion Date

2015-08-31

Brief Summary

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The main objective of this observational study was to describe medication-taking behavior of patients treated with denosumab for postmenopausal osteoporosis (PMO) at 12 and 24 months.

Detailed Description

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The decision to treat patients with denosumab was made independent of and before their enrolment in the study. No study drug was administered as part of the study.

Conditions

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Postmenopausal Osteoporosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Indicated for treatment of osteoporosis in postmenopausal women at increased risk of fractures according to the approved Regional Prescribing Information (eg, EU SmPC in Germany, Austria, Greece and Belgium).
* Enrolled into the study within 4 weeks of receiving their first injection of Prolia® according to the approved Regional Prescribing Information (eg, EU SmPC in Germany, Austria, Greece and Belgium).
* Appropriate written informed consent has been obtained (as required per local country regulations).

Exclusion Criteria

* Patient is currently enrolled in or has been enrolled within the prior 6 months in a study involving any investigational procedure, device or drug.
* Contraindicated for treatment with Prolia® according to the approved Regional Prescribing Information (eg, EU SmPC in Germany, Austria, Greece and Belgium).
* Participation in ongoing or previous denosumab clinical trials.
* Patient has any kind of disorder that, in the opinion of the investigator, may compromise the ability of the patient to give written informed consent.
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Amgen

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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MD

Role: STUDY_DIRECTOR

Amgen

Locations

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Graz, , Austria

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Graz, , Austria

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Klagenfurt, , Austria

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Landeck, , Austria

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Leibnitz, Styria, , Austria

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Lieboch, , Austria

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Salzburg, , Austria

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Sankt Stefan, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Voitsberg, , Austria

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Vöcklabruck, , Austria

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Aalst, , Belgium

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Aarschot, , Belgium

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Alsemberg, , Belgium

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Baisy-Thy, , Belgium

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Blankenberge, , Belgium

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Bornem, , Belgium

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Brain-Le-Comte, , Belgium

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Bruges, , Belgium

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Brussels, , Belgium

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Brussels, , Belgium

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Chênée, , Belgium

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Dour, , Belgium

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Eisden Maasmechelen, , Belgium

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Genk, , Belgium

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Ghent, , Belgium

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Gribomont, , Belgium

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Grimbergen, , Belgium

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Haine-Saint-Paul, , Belgium

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Halen, , Belgium

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Ham, , Belgium

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Ham-sur-Heure, , Belgium

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Harelbeke, , Belgium

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Hasselt, , Belgium

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Heusden, , Belgium

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Heusy, , Belgium

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Hoeilaart, , Belgium

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Knokke-Heist, , Belgium

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Kortrijk, , Belgium

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Kraainem, , Belgium

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Landen, , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Lummen, , Belgium

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Marchovelette, , Belgium

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Mont-Godinne, , Belgium

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Mont-sur-Marchienne, , Belgium

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Mouscron, , Belgium

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Natoye, , Belgium

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Paal-Beringen, , Belgium

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Retie, , Belgium

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Seraing, , Belgium

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Steenokkerzeel, , Belgium

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Stoumont, , Belgium

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Thuilles, , Belgium

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Tongeren, , Belgium

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Vilvoorde, , Belgium

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Vlijtingen-Riemst, , Belgium

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Wetteren, , Belgium

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Aachen, , Germany

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Augsburg, , Germany

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Bad Kreuznach, , Germany

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Bad Reichenhall, , Germany

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Bammental, , Germany

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Bautzen, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Berlin, , Germany

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Cottbus, , Germany

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Düsseldorf, , Germany

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Dresden, , Germany

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Erfurt, , Germany

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Erlangen, , Germany

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Freiburg im Breisgau, , Germany

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Freudenstadt, , Germany

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Friedrichroda, , Germany

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Hamburg, , Germany

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Hamburg, , Germany

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Hamburg, , Germany

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Hanover, , Germany

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Hattingen, , Germany

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Heidelberg, , Germany

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Heinsberg, , Germany

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Herne, , Germany

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Hettstedt, , Germany

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Hildesheim, , Germany

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Immenstadt im Allgäu, , Germany

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Lahnstein, , Germany

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Leipzig, , Germany

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Leipzig, , Germany

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Leverkusen, , Germany

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Marburg, , Germany

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Müllheim, , Germany

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München, , Germany

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München, , Germany

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München, , Germany

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Münster, , Germany

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Mönchengladbach-Rheydt, , Germany

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Nürnbrecht, , Germany

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Neustadt, , Germany

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Nienburg, , Germany

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Osnabrück, , Germany

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Potsdam, , Germany

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Saarbrücken, , Germany

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Stockach, , Germany

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Ulm, , Germany

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Völklingen, , Germany

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Wadgassen, , Germany

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Würzburg, , Germany

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Wittstock, , Germany

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Zerbst, , Germany

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Athens, , Greece

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Athens, , Greece

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Athens, , Greece

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Athens, , Greece

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Athens, , Greece

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Athens, , Greece

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Athens, , Greece

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Athens, , Greece

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Athens, , Greece

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Chaidari, Athens, , Greece

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Chania, Crete, , Greece

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Heraklion, , Greece

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Heraklion, Crete, , Greece

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Livadeia, , Greece

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Maroussi, Athens, , Greece

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Pátrai, , Greece

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Pátrai, , Greece

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Thessaloniki, , Greece

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Thessaloniki, , Greece

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Thessaloniki, , Greece

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Thessaloniki, , Greece

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Thessaloniki, , Greece

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Thessaloniki, , Greece

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Thessaloniki, , Greece

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Countries

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Austria Belgium Germany Greece

References

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Fahrleitner-Pammer A, Papaioannou N, Gielen E, Feudjo Tepie M, Toffis C, Frieling I, Geusens P, Makras P, Boschitsch E, Callens J, Anastasilakis AD, Niedhart C, Resch H, Kalouche-Khalil L, Hadji P. Factors associated with high 24-month persistence with denosumab: results of a real-world, non-interventional study of women with postmenopausal osteoporosis in Germany, Austria, Greece, and Belgium. Arch Osteoporos. 2017 Dec;12(1):58. doi: 10.1007/s11657-017-0351-2. Epub 2017 Jun 22.

Reference Type BACKGROUND
PMID: 28643265 (View on PubMed)

Related Links

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http://www.amgentrials.com

AmgenTrials clinical trials website

Other Identifiers

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20110126

Identifier Type: -

Identifier Source: org_study_id

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