Drainage or Pericardiocentesis (DROP) Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention

NCT ID: NCT01665495

Last Updated: 2012-08-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

122 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Study Completion Date

2014-12-31

Brief Summary

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The DROP study is a prospective, multi center, randomized, open-label trial to test the efficacy and safety of extended catheter pericardial drainage in patients with non-malignant pericardial effusions.

Detailed Description

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The trial will compared the efficacy and safety of pericardiocentesis alone compared with extended pericardial catheter drainage for the prevention of recurrent effusions in patients with non-malignant pericardial effusions requiring intervention.

Conditions

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Pericardial Effusion

Keywords

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pericardial effusion cardiac tamponade pericardiocentesis pericardial drainage prevention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Pericardiocentesis

Pericardial fluid drained by simple echo-guided pericardiocentesis

Group Type NO_INTERVENTION

No interventions assigned to this group

Extended pericardial drainage

Extended pericardial drainage will include pericardiocentesis followed by an intermittent pericardial catheter drainage. Pericardial drainage will be kept till daily fluid return\<30ml

Group Type ACTIVE_COMPARATOR

Extended pericardial drainage by catheter

Intervention Type PROCEDURE

Extended pericardial drainage will be done after pericardiocentesis by the insertion of a catheter to intermittently drain pericardial fluid till daily fluid return\<30 ml.

Interventions

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Extended pericardial drainage by catheter

Extended pericardial drainage will be done after pericardiocentesis by the insertion of a catheter to intermittently drain pericardial fluid till daily fluid return\<30 ml.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* adult patients
* pericardial effusion requiring pericardiocentesis
* non-malignant etiology

Exclusion Criteria

* known neoplastic etiology
* known bacterial etiology
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Maria Vittoria Hospital

OTHER

Sponsor Role lead

Responsible Party

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Massimo Imazio

Cardiologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Massimo Imazio, MD

Role: PRINCIPAL_INVESTIGATOR

Cardiology Department, Maria Vittoria Hospital

Locations

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Ospedali Riuniti

Bergamo, , Italy

Site Status RECRUITING

Ospedale Regionale San Maurizio

Bolzano, , Italy

Site Status ACTIVE_NOT_RECRUITING

Ospedale Niguarda

Milan, , Italy

Site Status RECRUITING

Ospedale degli Infermi

Rivoli, , Italy

Site Status ACTIVE_NOT_RECRUITING

Cardiology Department, Maria Vittoria Hospital

Torino, , Italy

Site Status RECRUITING

Cardiology Department, Ospedale San Giovanni Bosco

Torino, , Italy

Site Status RECRUITING

Ospedale Mauriziano

Torino, , Italy

Site Status ACTIVE_NOT_RECRUITING

Countries

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Italy

Central Contacts

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Massimo Imazio, MD FESC

Role: CONTACT

Phone: +390114393391

Email: [email protected]

Riccardo Belli, MD FESC

Role: CONTACT

Phone: +390114393557

Facility Contacts

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Antonio Brucato, MD

Role: primary

Anna Gandino, MD

Role: primary

Massimo Imazio, MD,FESC

Role: primary

Massimo Minelli, MD

Role: primary

References

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Imazio M, Belli R, Beqaraj F, Giammaria M, Lestuzzi C, Hoit B, LeWinter M, Spodick DH, Adler Y; DROP Investigators. DRainage Or Pericardiocentesis alone for recurrent nonmalignant, nonbacterial pericardial effusions requiring intervention: rationale and design of the DROP trial, a randomized, open-label, multicenter study. J Cardiovasc Med (Hagerstown). 2014 Jun;15(6):510-4. doi: 10.2459/JCM.0b013e3283621d26.

Reference Type DERIVED
PMID: 23867908 (View on PubMed)

Other Identifiers

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72/16/11

Identifier Type: -

Identifier Source: org_study_id