Study of NMB Drug Ejecting Balloon for Arteriovenous Fistulae

NCT ID: NCT01646788

Last Updated: 2012-07-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2015-01-31

Brief Summary

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The purpose of this study is to demonstrate the safety and effectiveness of the use of NMB's percutaneous transluminal angioplasty (PTA) for the treatment of obstructive lesions of Arteriovenous (AV) Dialysis Fistulae/Grafts.

Detailed Description

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Conditions

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Obstructive Lesions of Arteriovenous Dialysis Fistulae

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Experimental

NMB's PTA Balloon catheter with Paclitaxel drug

Group Type EXPERIMENTAL

NMB Paclitaxel Drug Ejecting Balloon

Intervention Type DEVICE

NMB's PTA Balloon catheter with drug

Interventions

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NMB Paclitaxel Drug Ejecting Balloon

NMB's PTA Balloon catheter with drug

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patient is 18 years old or older.
2. Native arteriovenous fistula or synthetic arteriovenous access graft performed/implanted more than 45 days before enrollment and at least one successful hemodialysis session performed.
3. Patient having obstructive lesion of native or synthetic arteriovenous dialysis fistulae/grafts, suitable for PTA procedure.
4. Patient who is willing and able to sign a written informed consent and that complies with procedures (including adherence to follow-up visits).

Exclusion Criteria

1. Women who are pregnant or breast-feeding and women of childbearing potential who do not use adequate contraception.
2. Previous participation in another study with any investigational drug or device within the past 30 days.
3. Life expectancy of less than 12 months or factors making clinical and/or angiographic follow-up difficult.
4. Known hypersensitivity to paclitaxel or structurally-related compounds.
5. Severe reaction to contrast agents that cannot be adequately premedicated prior to procedure.
6. Stenosis with corresponding thrombosis treated within 7 days before enrollment.
7. Patient with known contraindications for aspirin or other anticoagulant/antiplatelet therapy.
8. Infected grafts/fistulae.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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N.M.B. Medical Applications Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The Rabin Medical Center, Hasharon Hospital

Petah Tikva, , Israel

Site Status

Countries

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Israel

Central Contacts

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Eli Atar, MD

Role: CONTACT

Phone: 972-3-9376389

Email: [email protected]

Other Identifiers

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NMB AVS HSR

Identifier Type: -

Identifier Source: org_study_id