Tramadol Infiltration for Tonsillectomy

NCT ID: NCT01636700

Last Updated: 2015-07-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2011-10-31

Study Completion Date

2014-10-31

Brief Summary

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The purpose of this study is to evaluate the analgesic effect and IL-6 after tramadol infiltration or intravenous for tonsillectomy.

Detailed Description

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The study will be prospective, double-blind, randomized study of 40 children aged ≥ 4 and ≤ 12 years undergoing tonsillectomy under general anesthesia.

Patients will be allocated into two groups. Group 1 patients will receive tramadol 2 mg / kg intravenously and saline 0.9% infiltration in tonsils; group 2, will receive tramadol 2 mg / kg infiltration and intravenous saline.

There will be evaluated: postoperative pain intensity by facial scale, supplementary analgesics and interleukin-6. For statistical analysis of the results will be used parametric and nonparametric tests, taking into account the nature of the variables. The level of statistical significance will be set at \< 0.05.

Conditions

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Postoperative Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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tramadol infiltration

infiltration of tramadol 2mg/kg

Group Type ACTIVE_COMPARATOR

Tramadol 2mg/kg

Intervention Type DRUG

2mg/kg

Saline solution

Infiltration of saline

Group Type PLACEBO_COMPARATOR

Saline solution

Intervention Type DRUG

saline solution- 1 dose

Interventions

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Tramadol 2mg/kg

2mg/kg

Intervention Type DRUG

Saline solution

saline solution- 1 dose

Intervention Type DRUG

Other Intervention Names

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Opioid Placebo

Eligibility Criteria

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Inclusion Criteria

* children aged ≥ 4 and ≤ 12 years undergoing tonsillectomy

Exclusion Criteria

* coagulopathy,
* cancer,
* hepatic or renal alteration
Minimum Eligible Age

4 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Federal University of São Paulo

OTHER

Sponsor Role lead

Responsible Party

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Rioko Kimiko Sakata

Pain Clinic Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rioko K Sakata

Role: STUDY_DIRECTOR

Universidade Federal de São Paulo

Locations

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Universidade Federal de São Paulo

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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CEP2011

Identifier Type: -

Identifier Source: org_study_id

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