STEMI Versus NSTEMI: Clinical and Angiographic Differences

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2012-05-31

Brief Summary

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The purpose of this study is to assess differences in the risk profile and in the coronary angiographic presentation between STEMI and NSTEMI. Moreover possible relationship between myocardial infarction presentation and renal function will be investigated.

Detailed Description

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Assessment of risk profile. Diabetes mellitus diagnosed when fasting blood glucose (FBG) was \>= 126mg/dL or if patients were taking oral hypoglycaemic drugs or were on insulin treatment. Hypertension defined as blood pressure \>= 140/90 mmHg or history of antihypertensive treatment. Hypercholesterolemia,adjudicated when cholesterol levels were \>= 200 mg/dL or with patients on lipid lowering treatment. Hypertriglyceridemia adjudicated on fasting triglyceride levels\>= 200 mg/dL or triglyceride-lowering therapy . Obesity, defined as BMI \>= 30 kg/m2.

Patients with STEMI, who had not been previously treated with thrombolysis, and those who had been undergone to an unsuccessful thrombolysis, as well as patients with NSTEMI with a TIMI score\> 3 who were immediately referred to the Cat Lab and whenever possible treated with PTCA and stenting of the culprit lesion. The other patients who were referred to Cat Lab within 48 hours from the beginning of chest pain, unless their general conditions did not strongly suggest to delay the procedure after 2 more days.

Conditions

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Acute Coronary Syndrome

Keywords

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myocardial infarction coronary angiography STEMI NSTEMI

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients admitted in the coronary care unit (CCU) of the Department of Clinical and Experimental Medicine at the Federico 2nd University Hospital;
* Patient with indication to angiographic study even if not immediately;
* Patients referred to CCU with the diagnosis of acute myocardial infraction (AMI), type STEMI, or NSTEMI, based on pre-admission assessment of troponin I (TpI) and myocardial band creatin kinase (CK-MB;
* Diagnosis of NSTEMI/STEMI performed according to standard criteria

Exclusion Criteria

* Patients who could not undergo angiographic study

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Ferrara Liberato Aldo

Associate Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Giovanni de Simone, MD

Role: STUDY_DIRECTOR

Federico 2nd University of Naples

Locations

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CCU Dipartimento Assistenziale di Clinica Medica

Naples, , Italy

Site Status

Countries

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Italy

References

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Ferrara LA, Staiano L, Di Fronzo V, Ferrara F, Sforza A, Mancusi C, de Simone G. Type of myocardial infarction presentation in patients with chronic kidney disease. Nutr Metab Cardiovasc Dis. 2015 Feb;25(2):148-52. doi: 10.1016/j.numecd.2014.11.002. Epub 2014 Nov 11.

Reference Type DERIVED

PMID: 25511783 (View on PubMed)

Ferrara LA, Russo BF, Gente R, Esposito G, Rapacciuolo A, de Simone G. STEMI and NSTEMI: a mono versus a multivessel disease? Int J Cardiol. 2013 Oct 3;168(3):2905-6. doi: 10.1016/j.ijcard.2013.03.154. Epub 2013 May 3. No abstract available.