Performance-based Reinforcement to Enhance Cognitive Remediation Therapy

NCT ID: NCT01633138

Last Updated: 2020-03-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Study Completion Date

2014-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate whether monetary reinforcement for performance will enhance the effects of cognitive remediation therapy for substance users seeking treatment at an outpatient facility.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Forty individuals seeking treatment for an alcohol or cocaine use disorder at the Substance Abuse Treatment Unit (SATU) will be randomized to receive cognitive remediation therapy with or without additional compensation based on performance. Participants will use the computerized cognitive remediation program (PSSCogRehab 2012) three times per week for four weeks. The primary outcome measure will be an improved performance on the computerized tasks, with secondary outcomes of changes in cognitive functioning (e.g., attention, concentration, memory) as measured by neuropsychological tests between baseline and post-treatment.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Substance-Related Disorders Mental Disorders

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

CRT-S

Cognitive Remediation Therapy - Standard

Group Type ACTIVE_COMPARATOR

Cognitive Remediation Therapy - Standard

Intervention Type BEHAVIORAL

Computerized cognitive remediation therapy provided three times per week for four weeks

CRT-CM

Cognitive Remediation Therapy plus Contingency Management

Group Type EXPERIMENTAL

Cognitive Remediation Therapy plus Contingency Management

Intervention Type BEHAVIORAL

Standard cognitive remediation therapy plus monetary incentives based on performance provided three times per week for four weeks.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Cognitive Remediation Therapy - Standard

Computerized cognitive remediation therapy provided three times per week for four weeks

Intervention Type BEHAVIORAL

Cognitive Remediation Therapy plus Contingency Management

Standard cognitive remediation therapy plus monetary incentives based on performance provided three times per week for four weeks.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18 to 60 years old
* Primary Alcohol and/or Cocaine Abuse/Dependence Diagnosis
* Abstinence from all drugs/alcohol for 30 days
* Mild cognitive impairment
* Sufficiently stable and plan to commit to 4 weeks of outpatient treatment
* Fluent in English and 6th grade reading ability

Exclusion Criteria

* Severe cognitive impairment indicative of dementia
* Untreated bipolar or psychotic disorder
* Have current legal case pending such that incarceration during 4-week study is likely
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

Yale University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Brian D Kiluk, PhD

Role: PRINCIPAL_INVESTIGATOR

Yale University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Substance Abuse Treatment Unit

New Haven, Connecticut, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

P50DA009241

Identifier Type: NIH

Identifier Source: secondary_id

View Link

1205010253

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Cognitive Stimulation in Adolescents
NCT01948674 COMPLETED PHASE2
Reinforcing Therapist Performance
NCT01016704 COMPLETED NA
Web-based CBT4CBT for Alcohol
NCT01615497 COMPLETED NA