Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome

NCT ID: NCT01632137

Last Updated: 2014-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

564 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the efficacy and safety of rebamipide ophthalmic suspension in subjects with dry eye syndrome.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dry Eye Syndrome

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Placebo (vehicle)

Group Type PLACEBO_COMPARATOR

Placebo (vehicle)

Intervention Type DRUG

Instill one drop into each eye 4 times a day for 4 weeks.

Rebamipide 2% ophthalmic suspension

Group Type EXPERIMENTAL

Rebamipide 2% ophthalmic suspension

Intervention Type DRUG

Instill one drop into each eye 4 times a day for 4 weeks.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Rebamipide 2% ophthalmic suspension

Instill one drop into each eye 4 times a day for 4 weeks.

Intervention Type DRUG

Placebo (vehicle)

Instill one drop into each eye 4 times a day for 4 weeks.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* History of dry eye-related ocular symptoms for at least 20 months.
* Meet protocol-defined criteria for corneal and conjunctival staining.
* Meet protocol-defined criteria for ocular discomfort.

Exclusion Criteria

* Active anterior segment ocular disease other than dry eye syndrome.
* Inability to suspend the use of topical ophthalmic medications throughout the duration of the study.
* Inability to suspend the use of contact lenses for the duration of the study.
* Judged by the investigator to be ineligible for the study because of a past or concurrent systemic disease, or safety concerns.
* Received any other investigational product within 4 months before the screening visit.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Otsuka Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role collaborator

Kubota Vision Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Acucela Medical Monitor

Role: STUDY_DIRECTOR

Kubota Vision Inc.

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Phoenix, Arizona, United States

Site Status

Little Rock, Arkansas, United States

Site Status

Artesia, California, United States

Site Status

Glendale, California, United States

Site Status

Inglewood, California, United States

Site Status

San Diego, California, United States

Site Status

Wheat Ridge, Colorado, United States

Site Status

Fort Myers, Florida, United States

Site Status

Miami, Florida, United States

Site Status

Plantation, Florida, United States

Site Status

Stuart, Florida, United States

Site Status

Tampa, Florida, United States

Site Status

Morrow, Georgia, United States

Site Status

Baton Rouge, Louisiana, United States

Site Status

Lutherville, Maryland, United States

Site Status

Kansas City, Missouri, United States

Site Status

St Louis, Missouri, United States

Site Status

Washington, Missouri, United States

Site Status

Las Vegas, Nevada, United States

Site Status

Princeton, New Jersey, United States

Site Status

Rochester, New York, United States

Site Status

Rockville Centre, New York, United States

Site Status

Valley Stream, New York, United States

Site Status

Wantagh, New York, United States

Site Status

Ashville, North Carolina, United States

Site Status

Charlotte, North Carolina, United States

Site Status

Cleveland, Ohio, United States

Site Status

Mason, Ohio, United States

Site Status

Pittsburgh, Pennsylvania, United States

Site Status

Chattanooga, Tennessee, United States

Site Status

Memphis, Tennessee, United States

Site Status

Houston, Texas, United States

Site Status

Salt Lake City, Utah, United States

Site Status

Norfolk, Virginia, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ACU-RED-301

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Study of TOP1630 for Dry Eye Syndrome
NCT03833388 COMPLETED PHASE2/PHASE3