Use Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-07-31

Study Completion Date

2013-07-31

Brief Summary

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The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.

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Detailed Description

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Conditions

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Periprosthetic Bone Loss in Total Knee Replacement

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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severe knee OA who are indicated for total knee arthroplasty

the woman who are indicated for TKR and are post menopausal will be recruited in this study. We will excluded the patients who had immune disease ,previous fracture of femur and end stage of renal disease

dual energy x-ray absorptiometry

Intervention Type RADIATION

before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months

Interventions

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dual energy x-ray absorptiometry

before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* severe knee osteoarthritis
* post menopausal women

Exclusion Criteria

* immune disease
* end stage of renal disease who receive dialysis
* history of fracture at ipsilateral distal femur

Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Responsible Party

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National Taiwan University Hospital

Use dual-energy x-ray absorptiometry and quantative microradiography to predict the periprosthetic bone loss in distal femur after total knee arthroplasty

Responsibility Role SPONSOR_INVESTIGATOR