Neuroblastoma Biology Study

NCT ID: NCT01587300

Last Updated: 2024-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-07-31

Study Completion Date

2099-12-31

Brief Summary

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Medical scientists want to find better ways to treat neuroblastoma and to find ways to prevent the tumor from growing back. To do this, they need more information about the characteristics of neuroblastoma cells. Therefore, they want to study samples of neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that may be related to the growth of neuroblastoma cells. Doctors and other medical scientists also want to find better ways to detect and measure neuroblastoma to improve the ability to follow the response of tumor cells to therapy.

Detailed Description

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The purposes of this study are:

To establish a storage place or bank of samples of blood, bone marrow, and/or tumor, and molecular components isolated from these samples from children with neuroblastoma. The stored specimens will be shared with laboratory researchers studying high risk neuroblastoma.

To collect clinical data (such as treatments received, date of diagnosis, tumor stage, etc) and radiology scans to provide this information as needed for the laboratory studies to be done on the specimens.

To obtain neuroblastoma tumor cells from tumor tissue, bone marrow, and/or blood to use to start cell lines, or tumor cells that will keep growing in the laboratory. These cell lines will be shared with laboratory researchers studying high risk neuroblastoma.

Conditions

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Neuroblastoma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients must be greater than or 31 days of age.
* Patients must have had a diagnosis of high risk neuroblastoma either by histological verification of neuroblastoma and/or demonstration of tumor cells in the bone marrow with increased urinary catecholamines.
* All patients with refractory or recurrent high risk neuroblastoma at NANT institutions are eligible regardless of disease status (including no measurable or evaluable tumor) as long as they undergo a disease evaluation and appropriate samples are submitted.
* Additionally, all patients with high risk neuroblastoma without relapse treated at a NANT institution are eligible if undergoing a disease evaluation, as long as Children's Oncology Group specimens are prioritized.
Minimum Eligible Age

31 Days

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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New Approaches to Neuroblastoma Therapy Consortium

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Shahab Asgharzadeh, MD

Role: STUDY_CHAIR

Children's Hospital Los Angeles

Locations

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Children's Hospital Los Angeles

Los Angeles, California, United States

Site Status RECRUITING

Lucille Salter Packer Children's Hospital, Stanford University

Palo Alto, California, United States

Site Status COMPLETED

UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, United States

Site Status RECRUITING

Children Hospital of Colorado

Aurora, Colorado, United States

Site Status RECRUITING

AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus

Atlanta, Georgia, United States

Site Status RECRUITING

University of Chicago, Comer Children's Hospital

Chicago, Illinois, United States

Site Status RECRUITING

Children's Hospital Boston

Boston, Massachusetts, United States

Site Status RECRUITING

C.S Mott Children's Hospital

Ann Arbor, Michigan, United States

Site Status RECRUITING

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status COMPLETED

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Site Status RECRUITING

Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status RECRUITING

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

Site Status NOT_YET_RECRUITING

University of Texas Southwestern

Dallas, Texas, United States

Site Status NOT_YET_RECRUITING

Cook Children's Medical Center - Fort Worth

Fort Worth, Texas, United States

Site Status RECRUITING

Seattle Children's Hospital

Seattle, Washington, United States

Site Status RECRUITING

Hospital for Sick Children

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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United States Canada

Central Contacts

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Araz Marachelian, MD

Role: CONTACT

323-361-5687

Facility Contacts

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Araz Marachelian, MD

Role: primary

Kieuhoa Vo, MD

Role: primary

Margaret Macy, MD

Role: primary

Kelly Goldsmith, MD

Role: primary

Ami Desai, MD

Role: primary

Suzanne Shusterman, MD

Role: primary

Rajen Mody, MD

Role: primary

Katherine Somers, MD

Role: primary

Keri Streby, MD

Role: primary

Yael Mosse, MD

Role: primary

Sara Federico, MD

Role: primary

Tanya Watt, MD

Role: primary

Chelsee Greer, DO

Role: primary

Mark Fluchel, MD

Role: primary

Daniel Morgenstern, MD

Role: primary

Other Identifiers

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N2004-05

Identifier Type: -

Identifier Source: org_study_id

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