Early Versus Delayed Cord Clamping at Term: Neurodevelopmental Outcomes in Swedish Infants at 4 Years of Age

NCT ID: NCT01581489

Last Updated: 2023-06-22

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 263 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-04-30
• Study Completion Date: 2013-08-31

Brief Summary

Delayed clamping of the umbilical cord might prevent or slow the onset of iron deficiency by increasing the infant's iron endowment at birth. Compared to early clamping, a delay in clamping in clamping of around 2-3 min provides an additional 25-40 mL of blood per kg of bodyweight to the newborn infant.

The results of previous intervention studies on delayed clamping are mixed, and few have followed the infants beyond the perinatal period. All longer follow up studies have been performed in low income countries except for the investigators earlier study, showing less iron deficiency and improved iron stores after delayed cord clamping at 4 months of age.

The main objective of the current study is to assess whether the time of cord clamping affects neurodevelopment at 4 years of age in a large sample of full-term, Swedish infants. The investigators hypothesis is that as delayed cord clamping improves iron stores at 4 months, this could affect the child's development positively.

Detailed Description

Project description

Iron deficiency is associated with neurodevelopmental delay and suboptimal cognitive function. Our hypothesis is that early cord clamping is associated with an increased risk for iron deficiency, and as a consequence increased risk for suboptimal infant development also in a country with high standard of living.

• Method

1. Study cohort Four-hundred full-term infants, born to healthy mothers after normal pregnancies, were randomized to early or delayed cord clamping (at a hospital which practiced early cord clamping as standard practice). The infants were born during the time-period April 2008 to May 2009. Pregnant women were considered eligible if they met the following criteria: non-smoking, healthy mother (no haemolytic disease, no treatment with any of the following drugs: anticonvulsants, antidepressants, thyroid hormone, insulin, chemotherapy or cortisone), normal pregnancy (no preeclampsia, no diabetes, no prolonged rupture of membranes or signs of infection), single birth, term pregnancy (gestational age 37 +0 until 41 +6 weeks + days), expected vaginal delivery with cephalic presentation. Furthermore, the mother should be able to master Swedish well enough to understand the meaning of the study. Mothers were given written and oral information about the trial at the maternal health care centre from 34 weeks of gestational age. Mothers fulfilling the inclusion criteria at the time of admission to the delivery ward were again given written and oral information about the study by the attending midwife and written informed consent was obtained. Randomization was performed in advance by computer in blocks of 20. When delivery was imminent, the midwife opened a sealed envelope containing the treatment allocation. The intervention in the early cord clamping (ECC) group consisted of double clamping of the umbilical cord within 10 seconds of the infant's delivery, and arterial and venous blood sampling from the clamped segment within 10 min. The intervention in the delayed cord clamping (DCC) group consisted of late (≥ 180 s) clamping of the umbilical cord and arterial and venous blood sampling from the unclamped cord within 30 seconds after birth, while the midwife was holding the child below the level of the uterus. In both randomization groups, all children were initially kept about 20 cm below the level of the mother's uterus for 30 seconds and then placed on their mother's chest. All other aspects of obstetric care during labour and delivery were managed according to the standard practice of care at the study hospital. Oxytocin was administered to all mothers immediately after cord clamping. The final participating mother-infant pairs available for statistical analysis were 189 in the ECC group and 193 in the DCC group.

2. Follow up at 4 years of age

Children will be asked to return for a follow up at 4 years of age for neuro-developmental testing including:

• Cognitive testing with WPPSI (Wechsler Preschool and Primary Scale of Intelligence)
• Behavioral assessment with SDQ (Strengths and Difficulties Questionnaire), a questionnaire for behavioural screening which is filled in by the parents
• Assessment of psychomotor development with ASQ (Ages and Stages Questionnaire), a questionnaire that is filled in by the parents
• Selected items from Movement ABC (Assessment Battery for Children)

Time plan The included children were born during the time period April 2008 to May 2009, and they will become 4 years during 2012 and 2013. We aim to test them at the age of 4 years (April 2012 to May 2013). Additional research ethics permission for the follow up has been approved. Permission to translate and use the Ages and Stages Questionnaire (ASQ) for scientific purposes, has been sought from the publisher Brooks Publishing (as already approved for the previous versions at 4, 12 and 36 months of age).

• Realization At approximately one month before the child's fourth birthday, the parents will receive a letter containing information about the study,including time and location for the testing, and the two questionnaires, SDQ and ASQ. The parents are asked to answer these questionnaires before the visit to the psychologist.

The parents has also been informed about the planned neurodevelopmental testing and questionnaires at 4 years of age when they had another scheduled visit when the child was three years of age. The parents have the opportunity to contact the research assistant who can change the time for the visit. After the neurodevelopmental testing, the parents will receive a written report, and if abnormal results are discovered, due action will be taken.

Conditions

Developmental Delay; Iron Deficiency

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Early cord clamping (ECC)

Early cord clamping consisted of early (=\< 10 s) clamping of the umbilical cord at birth.

Time to clamping of the umbilical cord after delivery

Intervention Type: PROCEDURE

The time after delivery of the newborn until the midwife stops the circulation in the umbilical cord with a clamp.

Delayed cord clamping (DCC)

Delayed cord clamping consisted of delayed (\>= 180 s) clamping of the umbilical cord at birth.

Time to clamping of the umbilical cord after delivery

Intervention Type: PROCEDURE

The time after delivery of the newborn until the midwife stops the circulation in the umbilical cord with a clamp.

Interventions

Time to clamping of the umbilical cord after delivery

The time after delivery of the newborn until the midwife stops the circulation in the umbilical cord with a clamp.

Intervention Type: PROCEDURE

Other Intervention Names

Immediate cord clamping; Late cord clamping; Deferred cord clamping

Eligibility Criteria

Inclusion Criteria

• Participant in the earlier cord clamping trial
• Age between 48 and 51 months

• Minimum Eligible Age: 48 Months
• Maximum Eligible Age: 51 Months
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Umeå University

OTHER

Sponsor Role: collaborator

Halmstad County Hospital

OTHER

Sponsor Role: collaborator

County Council of Halland, Sweden

OTHER_GOV

Sponsor Role: collaborator

Uppsala University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ola Andersson, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital of Halland, Halmstad

Barbro Lindquist, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospital of Halland, Halmstad

Lena Hellström-Westas, Professor

Role: STUDY_CHAIR

Uppsala University

Locations

Hospital of Halland, Halmstad

Halmstad, Halland County, Sweden

Countries

Sweden

References

Andersson O, Hellstrom-Westas L, Andersson D, Domellof M. Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: a randomised controlled trial. BMJ. 2011 Nov 15;343:d7157. doi: 10.1136/bmj.d7157.

Reference Type: BACKGROUND

PMID: 22089242 (View on PubMed)

Andersson O, Lindquist B, Lindgren M, Stjernqvist K, Domellof M, Hellstrom-Westas L. Effect of Delayed Cord Clamping on Neurodevelopment at 4 Years of Age: A Randomized Clinical Trial. JAMA Pediatr. 2015 Jul;169(7):631-8. doi: 10.1001/jamapediatrics.2015.0358.

Reference Type: RESULT

PMID: 26010418 (View on PubMed)

Other Identifiers

NATIBAR1213

Identifier Type: -

Identifier Source: org_study_id