Circulating SIRT6 Expression, Effect on Aging Quality

NCT ID: NCT01567176

Last Updated: 2019-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2012-09-30

Brief Summary

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This study follows the results of the COMPALICLAMP study (NCT00951392) where the investigators showed a differential expression of sirtuins protein isoforms, Sirt6, in muscle depending on the quality of aging. The investigators seek to confirm this difference in expression level of circulating leukocytes on a larger sample.

Detailed Description

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Conditions

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Aging

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Single Arm

Group Type OTHER

Blood sample

Intervention Type BIOLOGICAL

It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample

Interventions

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Blood sample

It is a single cross sectional study. All outcome measures will be taken during the investigation with physical examination, questionnaire and a blood sample

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Volunteers from the SUVIMAX 2 aging cohort
* Men and women
* Older than 60
* Subject with a global aging quality score of 1 or 3 in the SU.VI.MAX. 2 study
* Covered by Health Insurance System

Exclusion Criteria

* Subject not in compliance with the recommendation of French National Law
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Martine LAVILLE, Pr

Role: PRINCIPAL_INVESTIGATOR

Centre de recherche en nutrition humaine Rhone-Alpes

Locations

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Centre de recherche en nutrition humaine Rhone-Alpes

Pierre-Bénite, , France

Site Status

Centre de Recherche en Nutrition Humaine

Pierre-Bénite, , France

Site Status

Countries

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France

References

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Betry C, Meugnier E, Pflieger M, Grenet G, Hercberg S, Galan P, Kesse-Guyot E, Vidal H, Laville M. High expression of CPT1b in skeletal muscle in metabolically healthy older subjects. Diabetes Metab. 2019 Apr;45(2):152-159. doi: 10.1016/j.diabet.2018.01.018. Epub 2018 Feb 12.

Reference Type RESULT
PMID: 29657112 (View on PubMed)

Other Identifiers

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2011.674

Identifier Type: -

Identifier Source: org_study_id

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