Distress Tolerance and Buprenorphine

NCT ID: NCT01556087

Last Updated: 2015-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

59 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2015-08-31

Brief Summary

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The investigators propose that inability to tolerate the distress of opioid withdrawal and the negative affect associated with early abstinence are key factors in early illicit opioid lapse and subsequent buprenorphine treatment drop-out. Our intervention aimed at increasing distress tolerance is designed to increase treatment adherence.

Detailed Description

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Conditions

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Opioid Dependence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Distress Tolerance

7 sessions aimed at increasing distress tolerance skills

Group Type EXPERIMENTAL

Distress Tolerance

Intervention Type BEHAVIORAL

7 individual sessions aimed at increasing distress tolerance skills

Health Education

7 didactic health education sessions

Group Type PLACEBO_COMPARATOR

Health Education

Intervention Type BEHAVIORAL

7 individual sessions with didactic health education information

Interventions

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Distress Tolerance

7 individual sessions aimed at increasing distress tolerance skills

Intervention Type BEHAVIORAL

Health Education

7 individual sessions with didactic health education information

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* initiating buprenorphine treatment (which requires meeting current criteria for a DSM-IV diagnosis of opioid dependence)
* plan to remain on buprenorphine for at least three months
* age between 18 and 65 years
* if female of childbearing potential -- must be using adequate contraception (an intrauterine device, oral contraceptive, depot contraceptive, a barrier method "every time," or hysterectomy) as assessed by the study physician
* has at least two persons they regularly contact and can provide contact information for them
* speaks English sufficiently to understand instructions and assessments.

Exclusion Criteria

* current methadone maintenance treatment program participation
* medically necessary prescription opioid treatment (e.g., for chronic pain)
* current criteria for a DSM-IV diagnosis of substance dependence for sedative/hypnotic drugs, alcohol, stimulants, cocaine, inhalants, hallucinogens
* a diagnosis of organic brain disorder, bipolar disorder, schizophrenia, schizo-affective, schizophreniform, or paranoid disorder, or major depression (subjects who meet criteria for "substance-induced mood disorder," or dysthymia only will not be excluded)
* current suicidality on the Modified Scale for Suicidal Ideation
* use of daily psychotropic, antidepressant, or anxiolytic medication
* evidence of neuropsychological dysfunction as assessed by the study physician with confirmation with the Folstein Mini-Mental Status Examination
* anticipated major painful event (significant surgical procedure) in the coming 6 months
* probation/parole requirements that might interfere with protocol participation
* history of allergic reaction to buprenorphine or naloxone.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Butler Hospital

OTHER

Sponsor Role lead

Responsible Party

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Michael Stein, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Butler Hospital

Providence, Rhode Island, United States

Site Status

Countries

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United States

Other Identifiers

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DA032767

Identifier Type: -

Identifier Source: org_study_id

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