Comparison of Indacaterol 150 mcg Once Daily (o.d.) With Salmeterol/Fluticasone Propionate 50 mcg/500 mcg Twice Daily (b.i.d.)

NCT ID: NCT01555138

Last Updated: 2015-04-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

581 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-02-29

Study Completion Date

2014-02-28

Brief Summary

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The purpose of this study is to compare the effectiveness and safety of indacaterol with salmeterol /fluticasone propionate treatment in patients with moderate chronic obstructive pulmonary disease who, on entry to the study are being treated with salmeterol /fluticasone propionate.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Indacaterol

Indacaterol 150 mcg once daily (o.d.) delivered via the Novartis single dose dry power inhaler (SDDPI) (Onbrez® Breezhaler®)

Group Type EXPERIMENTAL

Indacaterol

Intervention Type DRUG

Indacaterol is delivered via a SDDPI.

Salmeterol/fluticasone propionate

Salmeterol 50 mcg /fluticasone propionate 500 mcg for inhalation delivered via a proprietary multi dose dry powder inhaler (MDDPI) device (Seretide® Accuhaler®) twice daily (b.i.d.)

Group Type ACTIVE_COMPARATOR

Salmeterol

Intervention Type DRUG

Salmeterol/fluticasone is delivered via a MDDPI

Interventions

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Indacaterol

Indacaterol is delivered via a SDDPI.

Intervention Type DRUG

Salmeterol

Salmeterol/fluticasone is delivered via a MDDPI

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with moderate COPD (Stage II)
* Able to perform spirometry assessments
* Current or ex-smokers
* On treatment with the fixed-dose combination of salmeterol 50 µg/fluticasone propionate 500 µg MDDPI b.i.d. for the treatment of COPD for ≥ 3 months directly preceding Visit 1.

Exclusion Criteria

* Having had a COPD exacerbation that required treatment with antibiotics and/or oral corticosteroids and/or hospitalization in the past year.
* Having a history of, or current ECG abnormality
* Asthma
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

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Novartis Investigative Site

Caba, Argentina, Argentina

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Buenos Aires, Buenos Aires, Argentina

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Buenos Aires, Buenos Aires, Argentina

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Buenos Aires, Buenos Aires, Argentina

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Buenos Aires, Buenos Aires, Argentina

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C A B A, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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Caba, Buenos Aires, Argentina

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La Plata, Buenos Aires, Argentina

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Mar del Plata, Buenos Aires, Argentina

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Mar del Plata, Buenos Aires, Argentina

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Quilmes, Buenos Aires, Argentina

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Córdoba, Córdoba Province, Argentina

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Villa María, Córdoba Province, Argentina

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Concepción del Uruguay, Entre Ríos Province, Argentina

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Mendoza, Mendoza Province, Argentina

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Mendoza, Mendoza Province, Argentina

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Santa Fe, Rosario, Argentina

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Salta, Salta Province, Argentina

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Rosario, Santa Fe Province, Argentina

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Santa Fe, Santa Fe Province, Argentina

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San Miguel de Tucumán, Tucumán Province, Argentina

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San Miguel de Tucumán, Tucumán Province, Argentina

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Buenos Aires, , Argentina

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Bogota, Cundinamarca, Colombia

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Barranquilla, , Colombia

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Bogotá, , Colombia

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Acquaviva delle Fonti, BA, Italy

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Cassano delle Murge, BA, Italy

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Treviglio, BG, Italy

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Bologna, BO, Italy

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Caserta, CE, Italy

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Forlì, FC, Italy

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Cona, FE, Italy

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Foggia, FG, Italy

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Cassino, FR, Italy

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Genova, GE, Italy

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Messina, ME, Italy

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Milan, MI, Italy

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Milan, MI, Italy

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Milan, MI, Italy

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Sesto San Giovanni, Mi, Italy

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Cittadella, PD, Italy

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Pisa, PI, Italy

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Pordenone, PN, Italy

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Parma, PR, Italy

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Pavia, PV, Italy

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Salerno, SA, Italy

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Cuasso al Monte, VA, Italy

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Tradate, VA, Italy

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Negrar, VR, Italy

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Verona, VR, Italy

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Wilayah Persekutuan, Kuala Lumpur, Malaysia

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Kuching, Sarawak, Malaysia

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Pulau Pinang, , Malaysia

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Guadalajara, Jalisco, Mexico

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Mexico City, Mexico City, Mexico

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Mexico City, Mexico City, Mexico

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Monterrey, Nuevo León, Mexico

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Querétaro City, Querétaro, Mexico

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San Luis Potosí City, San Luis Potosí, Mexico

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Breda, Netherlands, Netherlands

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Helmond, Netherlands, Netherlands

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Rotterdam, , Netherlands

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Loja, Andalusia, Spain

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Sanlúcar de Barrameda, Andalusia, Spain

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Valladolid, Castille and León, Spain

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Barcelona, Catalonia, Spain

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Canet de Mar, Catalonia, Spain

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Corbera de Llobregat, Catalonia, Spain

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Lleida, Catalonia, Spain

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Madrid, Madrid, Spain

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Pozuelo de Alarcón, Madrid, Spain

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Muenchenstein, Switzerland, Switzerland

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Basel, , Switzerland

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Biel, , Switzerland

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Gossau, , Switzerland

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Newcastle upon Tyne, Newcastle-upon-Tyne, United Kingdom

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Dundee, Perthshire, United Kingdom

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Hants, Southampton, United Kingdom

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Bradford, , United Kingdom

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Chester, , United Kingdom

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East Yorkshire, , United Kingdom

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Kettering, , United Kingdom

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Lancaster, , United Kingdom

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Surrey, , United Kingdom

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Countries

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Argentina Colombia Italy Malaysia Mexico Netherlands Spain Switzerland United Kingdom

Other Identifiers

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2011-003732-31

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

CQAB149B2401

Identifier Type: -

Identifier Source: org_study_id

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