Prospective Evaluation of Etravirine for HIV-infected Patients in Need of Lipid-lowering Drugs

NCT ID: NCT01543035

Last Updated: 2013-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

34 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-12-31

Study Completion Date

2013-08-31

Brief Summary

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Dyslipidaemia, characterized by raised triglyceride and low-density lipoprotein (LDL) cholesterol and reduced high-density lipoprotein (HDL) cholesterol levels, is common in HIV-infected individuals, and has been associated with HIV infection itself and antiretroviral therapy (ART). These abnormalities are well-established markers of cardiovascular (CVD) risk in the general population. Studies have suggested an increased risk of CVD associated with ART exposure over and above that conveyed by traditional cardiovascular risk factors. In HIV population to reduce lipid parameters, the most usual clinical strategy remains to add a statin treatment.

Recent studies suggested ART switch can represent an interesting alternative to statins to reduce lipid plasma levels.

The purpose of this study is to evaluate the frequency with which the replacement of LPV/r (lopinavir/ritonavir), ATZ/r (atazanavir/ritonavir), DRV/r (darunavir/ritonavir) or EFV (efavirenz) by ETR (Etravirin) in dyslipidemic patients with suppressed viremia would obviate the necessity to administer statins.

A prospective, phase III study in which the statin treatment of dyslipidemic HIV patients on antiretroviral drugs (ARVs) will be interrupted during 4 weeks is proposed.

At week 4, patients qualifying for a lipid lowering drug (calculated LDL-C≥ 3mmol/L) will replace EFV, LPV/r, DRV/r or ATZ/r by ETR. The proportion of patients not qualifying anymore for a statin treatment at 12 weeks (i.e. after 8 weeks of ETR treatment) will be determined. Additionally, the lipid level changes will be assessed at 12 weeks. Inflammatory markers will be measured at baseline, at drug switch and at the end of the study

Study drug will be provided by the drug manufacturer (Janssen-Cilag, AG). Compliance for study drug will be done at week-4 and week-12, Returned study medication will be counted and the amount notified on the Case Report Form (CRF).

Detailed Description

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Conditions

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HIV Infection

Keywords

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HIV infection lipid lowering drugs etravirine patient statin treatment EFV or boosted PI antiretroviral treatment

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Etravirine switch

Patients in need of lipid-lowering drug switched from boosted PI or EFV to Etravirine

Group Type EXPERIMENTAL

stop statin and switch to an antiretroviral drug with less impact on lipid metabolism

Intervention Type DRUG

Switch from a boosted PI or efavirenz based ART regimen to etravirine 400 mg/day once daily for patients in need of lipid lowering drugs (statin) after one month wash out of statin

Interventions

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stop statin and switch to an antiretroviral drug with less impact on lipid metabolism

Switch from a boosted PI or efavirenz based ART regimen to etravirine 400 mg/day once daily for patients in need of lipid lowering drugs (statin) after one month wash out of statin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* On statin treatment for at least 3 months (fluvastatin, simvastatin, pravastatin, rosuvastatin, or atorvastatin) for primary prevention of cardiovascular disease
* HIV Ribonucleic Acid (RNA) below 50 copies/mL, minimum duration 3 months
* On a stable (\> 3 months) ARV treatment including at least one of the following drugs: LPV/r, ATZ/r, DRV/r, or EFV
* No previous virological escape or virological escape documented with a genotype at the time of failure only showing a K103M mutation.

Exclusion Criteria

* Probability of cardiovascular complications of \> 20% according to the Swiss GSLA ("Groupe de travail Lipide et Athérosclérose"/Swiss Atherosclerosis Association) guidelines
* Previous cardiovascular disease (including stroke)
* Known diabetes
* Known intolerance of ETR
* Presence of a documented drug mutation (excluding the K103M)
* Regimen including non-boosted ATZ
* Known hyperlipidemia before ARV initiation
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Janssen-Cilag A.G., Switzerland

INDUSTRY

Sponsor Role collaborator

Calmy Alexandra

OTHER

Sponsor Role lead

Responsible Party

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Calmy Alexandra

MD, PhD, HIV department Director

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Calmy Alexandra, Md, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Geneva

Locations

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Universitätsspital Basel Klinik für Infektiologie & Spitalhygiene

Basel, , Switzerland

Site Status

Inselspital PKT2B / Poliklinik für Infektiologie

Bern, , Switzerland

Site Status

HUG /Division des Maladies infectieuses Unité VIH/SIDA

Geneva, , Switzerland

Site Status

Hôpital Neuchâtelois - La Chaux-de-Fonds Service des Maladies infectieuses

La Chaux-de-Fonds, , Switzerland

Site Status

CHUV / Service des maladies infectieuses Médecine 2

Lausanne, , Switzerland

Site Status

Kantonsspital / Infektiologie und Spitalhygiene Departement Innere Medizin

Sankt Gallen, , Switzerland

Site Status

Universitätsspital Zürich Division of Infectious Diseases and Hospital Epidemiology Department of Internal Medicine

Zurich, , Switzerland

Site Status

Countries

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Switzerland

References

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Mulligan K, Grunfeld C, Tai VW, Algren H, Pang M, Chernoff DN, Lo JC, Schambelan M. Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immune Defic Syndr. 2000 Jan 1;23(1):35-43. doi: 10.1097/00126334-200001010-00005.

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Reference Type DERIVED
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Other Identifiers

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ETRALL DR3215

Identifier Type: -

Identifier Source: org_study_id