Urine Proteome of Surgical Patients and Healthy Volunteers

NCT ID: NCT01538823

Last Updated: 2019-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

664 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-02-29

Study Completion Date

2016-07-31

Brief Summary

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The purpose of this study is to define early urinary biomarkers for diagnosis and prognosis of Renal Cell Carcinoma (RCC) with subsequent development of reliable, cost-effective, screening techniques.

Detailed Description

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Conditions

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Renal Cell Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1

Enrollment of surgical patients at Barnes Jewish Hospital (BJH) with a presumptive diagnosis of RCC and planned nephrectomy or partial nephrectomy.

No interventions assigned to this group

Group 2

Surgical patients at BJH with non urological cancers

No interventions assigned to this group

Group 3

Surgical patients at BJH with a presumptive diagnosis of RCC and planned nephrectomy or partial nephrectomy

No interventions assigned to this group

Group 4

Surgical patients at BJH with non urological cancers

No interventions assigned to this group

Group 5

Healthy volunteers with no history of cancer or renal disease

No interventions assigned to this group

Group 6

Patients at BJH/Washington University School of Medicine under post procedure surveillance for RCC recurrence and patients under treatment for metastatic disease.

No interventions assigned to this group

Group 7

Patients with a presumptive diagnosis of bladder cancer or prostate cancer

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 18 years and older
* Planned procedure with presumptive diagnosis of RCC, bladder or prostate cancer OR control patient undergoing non-urological surgery OR normal healthy volunteer OR post surgical patient with a diagnosis of RCC and under surveillance for reoccurrence of RCC or treatment of metastatic RCC
* Signed, informed consent

Exclusion Criteria

* Patients on dialysis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jerry Morrissey, PhD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Countries

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United States

References

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Hu R, Gupta R, Wang Z, Wang C, Sun H, Singamaneni S, Kharasch ED, Morrissey JJ. Bioplasmonic paper-based assay for perilipin-2 non-invasively detects renal cancer. Kidney Int. 2019 Dec;96(6):1417-1421. doi: 10.1016/j.kint.2019.08.020. Epub 2019 Sep 3.

Reference Type DERIVED
PMID: 31668633 (View on PubMed)

Other Identifiers

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201202051

Identifier Type: -

Identifier Source: org_study_id

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