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PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)

NCT ID: NCT01536821

Last Updated: 2013-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

81 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-05-31

Study Completion Date

2013-12-31

Brief Summary

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The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. Eligible participants will be asked to complete a single Study Visit at an affiliated research facility closest to their home.

Detailed Description

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Participants will be asked to complete a family history questionnaire, which will gather information about their family history of Parkinson's disease and related disorders. They will be asked to complete a single Study Visit, during which they will be asked to do some or all of the following:

1. Complete questionnaires regarding Parkinson's disease symptoms, medical history, mood, sleep, mental status, and activity level.
2. Be given a brief standard neurological examination.
3. Be given a scratch and sniff smell identification test.
4. Be asked to give a sample of approximately 2 tablespoons of blood.
5. Be asked to give a urine sample of approximately 1 tablespoon of urine.

Conditions

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Parkinson Disease

Keywords

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Parkinson disease Parkinson's Disease PD LRRK2 genetics genes

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

Positive for a LRRK2 mutation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Michael J. Fox Foundation for Parkinson's Research

OTHER

Sponsor Role collaborator

Indiana University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tatiana Foroud, PhD

Role: PRINCIPAL_INVESTIGATOR

Indiana University

Locations

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Cleveland Clinic Florida

Weston, Florida, United States

Site Status

Indiana University Medical Center

Indianapolis, Indiana, United States

Site Status

University of Iowa Hospitals

Iowa City, Iowa, United States

Site Status

Kansas University Medical Center

Kansas City, Kansas, United States

Site Status

University of Maryland School of Medicine

Baltimore, Maryland, United States

Site Status

University of Nebraska

Omaha, Nebraska, United States

Site Status

Beth Israel Medical Center

New York, New York, United States

Site Status

Medical University of Ohio

Toledo, Ohio, United States

Site Status

Oregon Health & Science University

Portland, Oregon, United States

Site Status

University of Alberta

Edmonton, Alberta, Canada

Site Status

Countries

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United States Canada

Other Identifiers

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1105005340

Identifier Type: -

Identifier Source: org_study_id