HYdrogel Coil Versus Bare Platinum Coil in Recanalization Imaging Data Study

NCT ID: NCT01516658

Last Updated: 2019-10-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

431 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-06-30

Study Completion Date

2019-06-30

Brief Summary

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HYBRID study is prospective randomized open label controlled multi center trial, to compare Hydrocoil and bare platinum coil for recanalization after endovascular treatment of intracranial aneurysms.

Detailed Description

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At least one Hydrocoil have to use in Hydrocoil arm, and only bare platinum coil have to use in Control arm.

Primary endpoint is recanalization within 1 year after embolization, and secondary endpoint are:

1. aneurysmal rupture within 1 year after embolization
2. any event within 30 days after embolization
3. recanalization within 6 months after embolization
4. aneurysmal retreatment within 1 year after embolization
5. aneurysmal rupture and any death within 1 year after embolization
6. any stroke within 1 year after embolization
7. any stroke, death hemorrhagic event, aneurysmal recanalization or retreatment within 1 year after embolization
8. change in aneurysmal occlusion
9. any comlicaion within 1 year after embolization
10. %length of Hydrocoil, maximum diameter of aneurysm, volume embolization ratio.

Conditions

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Intracranial Aneurysm Subarachnoid Hemorrhage

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Hydrogel coil group

use Hydrogel Coil as much as be able to use

Group Type EXPERIMENTAL

Hydrogel coil

Intervention Type DEVICE

at least one Hydrogel coil have to use for embolization

Bare platinum coil group

use only bare platinum coil

Group Type ACTIVE_COMPARATOR

Bare platinum coil

Intervention Type DEVICE

only bare platinum coil have to use for embolization

Interventions

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Hydrogel coil

at least one Hydrogel coil have to use for embolization

Intervention Type DEVICE

Bare platinum coil

only bare platinum coil have to use for embolization

Intervention Type DEVICE

Other Intervention Names

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Hydrocoil HydroSoft HydroFrame detachable coil GDC Microvention

Eligibility Criteria

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Inclusion Criteria

* saccular intracranial aneurysm
* endovascular treatment scheduled within 60days after consent
* 20-79 years old
* unruptured, chronic SAH or acurte SAH Grade 1-III
* 7-20mm in size
* 1 year follow up possibel
* independent (mRS 0-2)
* document consent

Exclusion Criteria

* previous endovascular treated
* additional aneurysm scheduled of endovascular treatment
* pregnant
* ineligible for study
Minimum Eligible Age

20 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan

OTHER

Sponsor Role collaborator

Kobe City General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Nobuyuki Sakai

Director of Neurosurgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nobuyuki Sakai, MD, DMSc

Role: PRINCIPAL_INVESTIGATOR

Kobe City Medical Center General Hospital

Locations

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Nakamura Memorial Hospital

Sapporo, Hokkaido, Japan

Site Status

Kobe City General Hospital

Kobe, Hyōgo, Japan

Site Status

Countries

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Japan

Other Identifiers

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UMIN000006748

Identifier Type: OTHER

Identifier Source: secondary_id

TRIBRAIN1119

Identifier Type: -

Identifier Source: org_study_id

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