LOXL1 Polymorphism in Pseudoexfoliation Syndrome

NCT ID: NCT01515735

Last Updated: 2012-01-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-12-31

Study Completion Date

2012-12-31

Brief Summary

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To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.

Detailed Description

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To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.

And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing.

Conditions

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Pseudoexfoliation Syndrome

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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pseudoexfoliation

The study group composted of the patients with pseudoexfoliation syndrome

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of Pseudoexfoliation

Exclusion Criteria

* medical condition that peripheral blood sampling cannot be done
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Changwon Kee, M.D., PhD

Role: STUDY_CHAIR

Samsung Medical Center

Locations

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Samsung medical center

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Changwon Kee, M.D., Ph.D.

Role: CONTACT

82-2-3410-3564

Facility Contacts

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Changwon Kee, M.D., Ph.D

Role: primary

82-2-3410-3564

References

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Mori K, Imai K, Matsuda A, Ikeda Y, Naruse S, Hitora-Takeshita H, Nakano M, Taniguchi T, Omi N, Tashiro K, Kinoshita S. LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population. Mol Vis. 2008 Jun 5;14:1037-40.

Reference Type RESULT
PMID: 18552979 (View on PubMed)

Fuse N, Miyazawa A, Nakazawa T, Mengkegale M, Otomo T, Nishida K. Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese. Mol Vis. 2008 Jul 21;14:1338-43.

Reference Type RESULT
PMID: 18648524 (View on PubMed)

Other Identifiers

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2011-06-035

Identifier Type: -

Identifier Source: org_study_id

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