Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis

NCT ID: NCT01510860

Last Updated: 2019-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2010-07-31

Brief Summary

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The purpose of this study is to compare the efficacy of Ursofalk 500 mg tablets versus Ursofalk 500 mg capsules in the treatment of Primary Biliary Cirrhosis (PBC).

Detailed Description

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Conditions

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Primary Biliary Cirrhosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Ursodeoxycholic acid (UDCA)250 mg

UDCA 250 mg capsule

Group Type ACTIVE_COMPARATOR

UDCA (Ursodeoxycholic acid)

Intervention Type DRUG

250 mg

Ursodeoxycholic acid (UDCA)500 mg

UDCA 500 mg tablet

Group Type EXPERIMENTAL

UDCA (Ursodeoxycholic acid)

Intervention Type DRUG

500 mg

Interventions

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UDCA (Ursodeoxycholic acid)

250 mg

Intervention Type DRUG

UDCA (Ursodeoxycholic acid)

500 mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Negative pregnancy
* Signed informed consent
* Histologically proven non-cirrhotic liver disease

Exclusion Criteria

* histologically proven cirrhosis
* PBC stage II+IV
* Positive HIV serology
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dr. Falk Pharma GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christian Rust, MD

Role: PRINCIPAL_INVESTIGATOR

Klinikum Grosshadern Munich

Locations

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Klinikum Grosshadern

Munich, , Germany

Site Status

Countries

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Germany

References

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Hopf C, Grieshaber R, Hartmann H, Hinrichsen H, Eisold M, Cordes HJ, Greinwald R, Rust C. Therapeutic Equivalence of Ursodeoxycholic Acid Tablets and Ursodeoxycholic Acid Capsules for the Treatment of Primary Biliary Cirrhosis. Clin Pharmacol Drug Dev. 2013 Jul;2(3):231-6. doi: 10.1002/cpdd.24. Epub 2013 Apr 15. No abstract available.

Reference Type RESULT
PMID: 27121784 (View on PubMed)

Other Identifiers

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URT-15/PBC

Identifier Type: -

Identifier Source: org_study_id

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