Comparative Study Between Early Vitrectomy and Observation for Spontaneous Closure of Traumatic Macular Hole

NCT ID: NCT01509092

Last Updated: 2014-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-01-31

Study Completion Date

2014-06-30

Brief Summary

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The purpose of this study is to compare the anatomical and visual recovery of eyes with traumatic macular hole (TMH) following either early vitrectomy or 6-month observation.

Detailed Description

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Patients who received vitrectomy immediately after the injury were compared with patients who were observed for six months for spontaneously closure.The closure rate, foveal microstructure, and final visual acuity were analyzed.

Conditions

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Trauma Macular Hole

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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obervation

patients in this arm received 6-months observation alone after injury

Group Type NO_INTERVENTION

No interventions assigned to this group

Surgical intervention

patients in this arm received vitrectomy surgery as soon as possible after injury

Group Type ACTIVE_COMPARATOR

vitrectomy surgery

Intervention Type PROCEDURE

"pars plana vitrectomy +internal limiting membrane peeling" done immediately after the identification of the macular hole

Interventions

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vitrectomy surgery

"pars plana vitrectomy +internal limiting membrane peeling" done immediately after the identification of the macular hole

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* closed globe injury
* identification of full-thickness macular hole by optical coherence tomography within one month after trauma

Exclusion Criteria

* open globe injury
* coexistence of idiopathic macular hole
* severe opaque in the visual axis caused by the injury(eg. severe cataract, severe vitreous hemorrhage)
* combined injuries requiring immediate surgical intervention (eg. lens dislocation, retinal detachment, cyclodialysis)
* coexistence of high myopia
* coexistence of choroidal rupture or subretinal hemorrhage within the diameter of 400μm from the center of the foveola
* coexistence of severe optic nerve injury (no light perception, positive afferent pupillary defect)
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University Third Hospital

OTHER

Sponsor Role lead

Responsible Party

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Zhi-zhong Ma

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zhi-Zhong Ma, M.D.

Role: PRINCIPAL_INVESTIGATOR

Peking University Third Hospital

Locations

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Eye Hospital of Hebei Province

Xingtai, Hebei, China

Site Status

Weifang Eye Hospital

Weifang, Shandong, China

Site Status

The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Site Status

Wenzhou Medical College

Wenzhou, Zhejiang, China

Site Status

China - Japan Friendship Hospital

Beijing, , China

Site Status

Peking University Third Hospital

Beijing, , China

Site Status

Southwest Eye hospital of Third Military Medical University

Chongqing, , China

Site Status

Shanghai Ninth People's Hospital Affiliated Shanghai JiaoTong University school of Medicine

Shanghai, , China

Site Status

Countries

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China

Other Identifiers

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PekingUTH-TMH-2011

Identifier Type: -

Identifier Source: org_study_id

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