Study of the Efficacy and Safety of the Combination of Two FDA Approved Oral Medications, Nebivolol and Valsartan for Treatment of Stage 1 or 2 Hypertension

NCT ID: NCT01508026

Last Updated: 2014-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

4161 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-01-31

Study Completion Date

2013-05-31

Brief Summary

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To evaluate the efficacy and safety of fixed-dose combination of nebivolol and valsartan compared to monotherapy and placebo in patients with stage 1 and stage 2 hypertension.

Detailed Description

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Conditions

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Stage 1 Hypertension Stage 2 Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Nebivolol and Valsartan Fixed Dose Combination 1

Fixed Dose Combination Nebivolol 5 mg and Valsartan 80 mg

Group Type EXPERIMENTAL

Nebivolol and Valsartan 1

Intervention Type DRUG

Fixed Dose Combination Nebivolol 5 mg and Valsartan 80 mg, oral administration, then dose doubled at Week 11 to Fixed Dose Combination Nebivolol 10 mg and Valsartan 160 mg, oral administration

Nebivolol and Valsartan Fixed Dose Combination 2

Fixed Dose Combination Nebivolol 5 mg and Valsartan 160 mg

Group Type EXPERIMENTAL

Nebivolol and Valsartan 2

Intervention Type DRUG

Fixed Dose Combination Nebivolol 5 mg and Valsartan 160 mg, oral administration then dose doubled at Week 11 to Fixed Dose Combination Nebivolol 10 mg and Valsartan 320 mg, oral administration

Nebivolol and Valsartan Fixed Dose Combination 3

Fixed Dose Combination Nebivolol 10 mg and Valsartan 160 mg

Group Type EXPERIMENTAL

Nebivolol and Valsartan 3

Intervention Type DRUG

Fixed Dose Combination Nebivolol 10 mg and Valsartan 160 mg, oral administration then dose doubled at Week 11 to Fixed Dose Combination Nebivolol 20 mg and Valsartan 320 mg, oral administration

Nebivolol Low Dose

Nebivolol Monotherapy 5 mg

Group Type EXPERIMENTAL

Nebivolol 1

Intervention Type DRUG

Nebivolol Monotherapy 5 mg, oral administration, then dose doubled to at Week 11 to Nebivolol Monotherapy 10 mg, oral administration

Nebivolol High Dose

Nebivolol Monotherapy 20 mg

Group Type EXPERIMENTAL

Nebivolol 2

Intervention Type DRUG

Nebivolol Monotherapy 20 mg, oral administration, then dose doubled to at Week 11 to Nebivolol Monotherapy 40mg, oral administration

Valsartan Low Dose

Valsartan Monotherapy 80 mg

Group Type EXPERIMENTAL

Valsartan 1

Intervention Type DRUG

Valsartan Monotherapy 80 mg, oral administration, then dose doubled to at Week 11 to Valsartan Monotherapy, 160 mg, oral administration

Valsartan High Dose

Valsartan Monotherapy 160 mg

Group Type EXPERIMENTAL

Valsartan 2

Intervention Type DRUG

Valsartan Monotherapy 160 mg, oral administration, then dose doubled to at Week 11 to Valsartan Monotherapy, 320 mg, oral administration

Placebo

Dose Matched placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Dose matched placebo, oral administration

Interventions

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Nebivolol and Valsartan 1

Fixed Dose Combination Nebivolol 5 mg and Valsartan 80 mg, oral administration, then dose doubled at Week 11 to Fixed Dose Combination Nebivolol 10 mg and Valsartan 160 mg, oral administration

Intervention Type DRUG

Nebivolol and Valsartan 2

Fixed Dose Combination Nebivolol 5 mg and Valsartan 160 mg, oral administration then dose doubled at Week 11 to Fixed Dose Combination Nebivolol 10 mg and Valsartan 320 mg, oral administration

Intervention Type DRUG

Nebivolol and Valsartan 3

Fixed Dose Combination Nebivolol 10 mg and Valsartan 160 mg, oral administration then dose doubled at Week 11 to Fixed Dose Combination Nebivolol 20 mg and Valsartan 320 mg, oral administration

Intervention Type DRUG

Nebivolol 1

Nebivolol Monotherapy 5 mg, oral administration, then dose doubled to at Week 11 to Nebivolol Monotherapy 10 mg, oral administration

Intervention Type DRUG

Nebivolol 2

Nebivolol Monotherapy 20 mg, oral administration, then dose doubled to at Week 11 to Nebivolol Monotherapy 40mg, oral administration

Intervention Type DRUG

Valsartan 1

Valsartan Monotherapy 80 mg, oral administration, then dose doubled to at Week 11 to Valsartan Monotherapy, 160 mg, oral administration

Intervention Type DRUG

Valsartan 2

Valsartan Monotherapy 160 mg, oral administration, then dose doubled to at Week 11 to Valsartan Monotherapy, 320 mg, oral administration

Intervention Type DRUG

Placebo

Dose matched placebo, oral administration

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female outpatients of age 18 years or above
* Patients diagnosed with stage 1 or stage 2 essential hypertension
* Normal physical examination findings, electrocardiogram (ECG) results and chest x-ray; or abnormal findings judged by the Investigator to be not clinically significant

Exclusion Criteria

* Secondary hypertension or severe hypertension
* Clinically significant cardiovascular disease or heart failure
* Clinical significant respiratory disease that would prohibit the use of a beta blocker
* A medical contraindication to discontinuing a current antihypertensive therapy
* History of Type 1 diabetes mellitus
* History of Severe Mental Illness except mild depression
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Forest Laboratories

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David B Bharucha, MD, PhD, FACC

Role: STUDY_DIRECTOR

Forest Laboratories

Locations

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Forest Investigative Site 1750

Birmingham, Alabama, United States

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Forest Investigative Site 1038

Birmingham, Alabama, United States

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Forest Investigative Site 1308

Birmingham, Alabama, United States

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Forest Investigative Site 1192

Birmingham, Alabama, United States

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Forest Investigative Site 1005

Birmingham, Alabama, United States

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Forest Investigative Site 1047

Foley, Alabama, United States

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Forest Investigative Site 1717

Gulf Shores, Alabama, United States

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Forest Investigative Site 1056

Mobile, Alabama, United States

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Forest Investigative Site 1719

Muscle Shoals, Alabama, United States

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Forest Investigative Site 1145

Glendale, Arizona, United States

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Forest Investigative Site 1703

Goodyear, Arizona, United States

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Forest Investigative Site 1757

Mesa, Arizona, United States

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Forest Investigative Site 1170

Phoenix, Arizona, United States

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Forest Investigative Site 1238

Phoenix, Arizona, United States

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Forest Investigative Site 1204

Phoenix, Arizona, United States

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Forest Investigative Site 1755

Phoenix, Arizona, United States

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Forest Investigative Site 1259

Phoenix, Arizona, United States

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Forest Investigative Site 1001

Phoenix, Arizona, United States

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Forest Investigative Site 1078

Scottsdale, Arizona, United States

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Forest Investigative Site 1225

Tempe, Arizona, United States

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Forest Investigative Site 1712

Tempe, Arizona, United States

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Forest Investigative Site 1089

Tempe, Arizona, United States

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Forest Investigative Site 1065

Tucson, Arizona, United States

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Forest Investigative Site 1340

Tucson, Arizona, United States

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Forest Investigative Site 1331

Tucson, Arizona, United States

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Forest Investigative Site 1290

Little Rock, Arkansas, United States

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Forest Investigative Site 1138

Little Rock, Arkansas, United States

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Forest Investigative Site 1371

Pine Bluff, Arkansas, United States

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Forest Investigative Site 1220

Searcy, Arkansas, United States

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Forest Investigative Site 1063

Buena Park, California, United States

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Forest Investigative Site 1743

Burbank, California, United States

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Forest Investigative Site 1006

Carmichael, California, United States

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Forest Investigative Site 1384

Chino, California, United States

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Forest Investigative Site 1190

Chula Vista, California, United States

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Forest Investigative Site 1178

Costa Mesa, California, United States

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Forest Investigative Site 1043

Diamond Bar, California, United States

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Forest Investigative Site 1362

Encinitas, California, United States

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Forest Investigative Site 1144

Fresno, California, United States

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Forest Investigative Site 1095

Fresno, California, United States

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Forest Investigative Site 1710

Garden Grove, California, United States

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Greenbrae, California, United States

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Forest Investigative Site 1370

Huntington Beach, California, United States

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Forest Investigative Site 1704

Huntington Park, California, United States

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Forest Investigative Site 1725

Huntington Park, California, United States

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Forest Investigative Site 1742

La Mesa, California, United States

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Forest Investigative Site 1381

Lomita, California, United States

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Forest Investigative Site 1706

Long Beach, California, United States

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Forest Investigative Site 1248

Los Angelas, California, United States

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Forest Investigative Site 1785

Los Angelas, California, United States

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Forest Investigative Site 1029

Los Angeles, California, United States

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Forest Investigative Site 1361

Los Angeles, California, United States

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Forest Investigative Site 1102

Los Angeles, California, United States

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Forest Investigative Site 1054

Mission Hills, California, United States

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Forest Investigative Site 1386

Moreno Valley, California, United States

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Forest Investigative Site 1756

Newport Beach, California, United States

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Forest Investigative Site 1181

Northridge, California, United States

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Orange, California, United States

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Palm Springs, California, United States

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Forest Investigative Site 1014

Paramount, California, United States

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Forest Investigative Site 1150

Pismo Beach, California, United States

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Forest Investigative Site 1009

Riverside, California, United States

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Forest Investigative Site 1241

Roseville, California, United States

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Sacramento, California, United States

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Forest Investigative Site 1193

Sacramento, California, United States

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Sacramento, California, United States

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Sacramento, California, United States

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San Bernardino, California, United States

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Forest Investigative Site 1189

San Diego, California, United States

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San Diego, California, United States

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Forest Investigative Site 1354

San Diego, California, United States

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San Diego, California, United States

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Forest Investigative Site 1106

San Diego, California, United States

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Forest Investigative Site 1027

San Francisco, California, United States

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San Marino, California, United States

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San Ramon, California, United States

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Santa Ana, California, United States

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Spring Valley, California, United States

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Stockton, California, United States

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Sylmar, California, United States

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Forest Investigative Site 1066

Temecula, California, United States

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Forest Investigative Site 1729

Tustin, California, United States

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Westlake Village, California, United States

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Forest Investigative Site 1162

Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Northglenn, Colorado, United States

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Forest Investigative Site 1400

Thornton, Colorado, United States

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Forest Investigative Site 1324

Bridgeport, Connecticut, United States

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Cromwell, Connecticut, United States

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Stamford, Connecticut, United States

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Waterbury, Connecticut, United States

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Forest Investigative Site 1159

Boca Raton, Florida, United States

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Bradenton, Florida, United States

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Brandon, Florida, United States

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Brooksville, Florida, United States

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Clearwater, Florida, United States

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Coral Gables, Florida, United States

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Coral Gables, Florida, United States

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Cutler Bay, Florida, United States

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Daytona Beach, Florida, United States

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Deerfield Beach, Florida, United States

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DeFuniak Springs, Florida, United States

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DeLand, Florida, United States

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Doral, Florida, United States

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Doral, Florida, United States

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Edgewater, Florida, United States

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Fort Lauderdale, Florida, United States

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Fort Lauderdale, Florida, United States

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Fort Lauderdale, Florida, United States

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Gainsville, Florida, United States

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Hallandale, Florida, United States

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Hialeah, Florida, United States

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Hialeah, Florida, United States

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Hollywood, Florida, United States

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Jacksonville, Florida, United States

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Jacksonville, Florida, United States

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Jacksonville, Florida, United States

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Jacksonville, Florida, United States

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Jupiter, Florida, United States

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Kissimmee, Florida, United States

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Kissimmee, Florida, United States

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Forest Investigative Site 1784

Miami, Florida, United States

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Forest Investigative Site 1364

Miami, Florida, United States

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Forest Investigative Site 1206

Miami, Florida, United States

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Forest Investigative Site 1397

Miami, Florida, United States

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Miami, Florida, United States

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Forest Investigative Site 1396

Miami, Florida, United States

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Forest Investigative Site 1154

Miami, Florida, United States

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Forest Investigative Site 1788

Miami, Florida, United States

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Forest Investigative Site 1223

Miami, Florida, United States

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Forest Investigative Site 1707

Miami, Florida, United States

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Forest Investigative Site 1282

Miami, Florida, United States

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Forest Investigative Site 1297

Miami Springs, Florida, United States

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Forest Investigative Site 1708

New Port Richey, Florida, United States

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Forest Investigative Site 1176

North Miami Beach, Florida, United States

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Forest Investigative Site 1284

Oldsmar, Florida, United States

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Opa-locka, Florida, United States

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Forest Investigative Site 1802

Orlando, Florida, United States

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Forest Investigative Site 1049

Orlando, Florida, United States

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Forest Investigative Site 1235

Orlando, Florida, United States

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Forest Investigative Site 1741

Ormond Beach, Florida, United States

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Forest Investigative Site 1003

Oviedo, Florida, United States

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Forest Investigative Site 1369

Palm Harbor, Florida, United States

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Forest Investigative Site 1079

Pembroke Pines, Florida, United States

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Pembroke Pines, Florida, United States

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Pembroke Pines, Florida, United States

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Forest Investigative Site 1161

Pembroke Pines, Florida, United States

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Forest Investigative Site 1166

Pembroke Pines, Florida, United States

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Forest Investigative Site 1224

Pembroke Pines, Florida, United States

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Forest Investigative Site 1075

Pembroke Pines, Florida, United States

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Forest Investigative Site 1368

Pinellas Park, Florida, United States

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Forest Investigative Site 1023

Plant City, Florida, United States

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Forest Investigative Site 1737

Ponte Vedra, Florida, United States

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Forest Investigative Site 1749

Port Orange, Florida, United States

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Forest Investigative Site 1069

Saint Cloud, Florida, United States

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Forest Investigative Site 1315

Saint Cloud, Florida, United States

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Forest Investigative Site 1739

South Miami, Florida, United States

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Forest Investigative Site 1243

St. Petersburg, Florida, United States

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Forest Investigative Site 1723

St. Petersburg, Florida, United States

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Forest Investigative Site 1730

St. Petersburg, Florida, United States

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Forest Investigative Site 1076

Tamarack, Florida, United States

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Forest Investigative Site 1032

Tampa, Florida, United States

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Forest Investigative Site 1302

Tampa, Florida, United States

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Forest Investigative Site 1120

Winter Haven, Florida, United States

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Forest Investigative Site 1281

Atlanta, Georgia, United States

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Forest Investigative Site 1745

Atlanta, Georgia, United States

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Forest Investigative Site 1080

Blue Ridge, Georgia, United States

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Forest Investigative Site 1236

Lilburn, Georgia, United States

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Forest Investigative Site 1389

Marietta, Georgia, United States

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Forest Investigative Site 1002

Marietta, Georgia, United States

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Forest Investigative Site 1390

Oakwood, Georgia, United States

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Forest Investigative Site 1333

Sandy Springs, Georgia, United States

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Forest Investigative Site 1332

Savannah, Georgia, United States

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Forest Investigative Site 1252

Snellville, Georgia, United States

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Forest Investigative Site 1353

Snellville, Georgia, United States

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Forest Investigative Site 1740

Stockbridge, Georgia, United States

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Forest Investigative Site 1173

Woodstock, Georgia, United States

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Forest Investigative Site 1018

Honolulu, Hawaii, United States

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Forest Investigative Site 1398

Blackfoot, Idaho, United States

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Forest Investigative Site 1727

Boise, Idaho, United States

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Forest Investigative Site 1387

Hayden Lake, Idaho, United States

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Forest Investigative Site 1004

Meridian, Idaho, United States

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Forest Investigative Site 1039

Nampa, Idaho, United States

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Forest Investigative Site 1790

Addison, Illinois, United States

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Forest Investigative Site 1093

Arlington Heights, Illinois, United States

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Forest Investigative Site 1747

Chicago, Illinois, United States

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Forest Investigative Site 1071

Chicago, Illinois, United States

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Forest Investigative Site 1752

Chicago, Illinois, United States

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Forest Investigative Site 1403

Hazel Crest, Illinois, United States

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Forest Investigative Site 1126

Morton, Illinois, United States

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O'Fallon, Illinois, United States

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Forest Investigative Site 1091

Evansville, Indiana, United States

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Evansville, Indiana, United States

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Forest Investigative Site 1147

Muncie, Indiana, United States

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Forest Investigative Site 1107

Augusta, Kansas, United States

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Forest Investigative Site 1345

Hutchinson, Kansas, United States

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Forest Investigative Site 1805

Lenexa, Kansas, United States

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Forest Investigative Site 1255

Mission, Kansas, United States

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Forest Investigative Site 1092

Newton, Kansas, United States

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Forest Investigative Site 1801

Crestview Hills, Kentucky, United States

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Forest Investigative Site 1366

Lexington, Kentucky, United States

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Forest Investigative Site 1770

Louisville, Kentucky, United States

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Forest Investigative Site 1177

Madisonville, Kentucky, United States

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Forest Investigative Site 1251

Baton Rouge, Louisiana, United States

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Forest Investigative Site 1215

Covington, Louisiana, United States

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Forest Investigative Site 1274

Eunice, Louisiana, United States

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Forest Investigative Site 1323

Metairie, Louisiana, United States

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Metairie, Louisiana, United States

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Forest Investigative Site 1285

New Orleans, Louisiana, United States

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New Orleans, Louisiana, United States

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Forest Investigative Site 1769

Auburn, Maine, United States

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Forest Investigative Site 1125

Baltimore, Maryland, United States

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Forest Investigative Site 1263

Baltimore, Maryland, United States

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Forest Investigative Site 1128

Lutherville, Maryland, United States

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Forest Investigative Site 1726

Haverhill, Massachusetts, United States

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Hyannis, Massachusetts, United States

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North Dartmouth, Massachusetts, United States

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Forest Investigative Site 1356

Watertown, Massachusetts, United States

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Forest Investigative Site 1336

Chelsea, Michigan, United States

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Flint, Michigan, United States

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Forest Investigative Site 1165

Kalamazoo, Michigan, United States

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Stevensville, Michigan, United States

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Traverse City, Michigan, United States

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Forest Investigative Site 1064

Troy, Michigan, United States

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Forest Investigative Site 1025

Belzoni, Mississippi, United States

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Forest Investigative Site 1057

Jackson, Mississippi, United States

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Olive Branch, Mississippi, United States

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Forest Investigative Site 1271

Picayune, Mississippi, United States

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Forest Investigative Site 1782

Kansas City, Missouri, United States

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Forest Investigative Site 1250

St Louis, Missouri, United States

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Forest Investigative Site 1326

Missoula, Montana, United States

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Forest Investigative Site 1028

Bellevue, Nebraska, United States

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Forest Investigative Site 1388

Fremont, Nebraska, United States

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Fremont, Nebraska, United States

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Forest Investigative Site 1035

Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Henderson, Nevada, United States

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Henderson, Nevada, United States

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Las Vegas, Nevada, United States

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Las Vegas, Nevada, United States

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Las Vegas, Nevada, United States

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Las Vegas, Nevada, United States

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Las Vegas, Nevada, United States

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Edison, New Jersey, United States

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Haddon Heights, New Jersey, United States

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Forest Investigative Site 1141

Linden, New Jersey, United States

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Paramus, New Jersey, United States

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Trenton, New Jersey, United States

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Forest Investigative Site 1338

Union, New Jersey, United States

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Forest Investigative Site 1761

Albuquerque, New Mexico, United States

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Forest Investigative Site 1796

Brooklyn, New York, United States

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Forest Investigative Site 1151

Buffalo, New York, United States

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Glen Falls, New York, United States

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Forest Investigative Site 1115

Rochester, New York, United States

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Forest Investigative Site 1040

Asheboro, North Carolina, United States

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Forest Investigative Site 1073

Burlington, North Carolina, United States

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Forest Investigative Site 1142

Cary, North Carolina, United States

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Forest Investigative Site 1733

Charlotte, North Carolina, United States

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Charlotte, North Carolina, United States

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Dunn, North Carolina, United States

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Greensboro, North Carolina, United States

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Greensboro, North Carolina, United States

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Greensboro, North Carolina, United States

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Forest Investigative Site 1306

Hickory, North Carolina, United States

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Hickory, North Carolina, United States

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Lenoir, North Carolina, United States

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Mooresville, North Carolina, United States

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Forest Investigative Site 1024

Raleigh, North Carolina, United States

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Raleigh, North Carolina, United States

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Salisbury, North Carolina, United States

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Shelby, North Carolina, United States

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Wilmington, North Carolina, United States

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Wilmington, North Carolina, United States

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Forest Investigative Site 1319

Winston-Salem, North Carolina, United States

Site Status

Forest Investigative Site 1405

Winston-Salem, North Carolina, United States

Site Status

Forest Investigative Site 1778

Winston-Salem, North Carolina, United States

Site Status

Forest Investigative Site 1203

Akron, Ohio, United States

Site Status

Forest Investigative Site 1210

Canal Fulton, Ohio, United States

Site Status

Forest Investigative Site 1012

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1721

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1280

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1798

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1732

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1718

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1062

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1050

Cincinnati, Ohio, United States

Site Status

Forest Investigative Site 1084

Cleveland, Ohio, United States

Site Status

Forest Investigative Site 1765

Columbus, Ohio, United States

Site Status

Forest Investigative Site 1395

Columbus, Ohio, United States

Site Status

Forest Investigative Site 1209

Delaware, Ohio, United States

Site Status

Forest Investigative Site 1201

Lyndhurst, Ohio, United States

Site Status

Forest Investigative Site 1246

Maumee, Ohio, United States

Site Status

Forest Investigative Site 1135

Mount Gilead, Ohio, United States

Site Status

Forest Investigative Site 1322

Perrysburg, Ohio, United States

Site Status

Forest Investigative Site 1231

Willoughby, Ohio, United States

Site Status

Forest Investigative Site 1713

Zanesville, Ohio, United States

Site Status

Forest Investigative Site 1195

Norman, Oklahoma, United States

Site Status

Forest Investigative Site 1184

Oklahoma City, Oklahoma, United States

Site Status

Forest Investigative Site 1305

Oklahoma City, Oklahoma, United States

Site Status

Forest Investigative Site 1759

Oklahoma City, Oklahoma, United States

Site Status

Forest Investigative Site 1392

Yukon, Oklahoma, United States

Site Status

Forest Investigative Site 1116

Ashland, Oregon, United States

Site Status

Forest Investigative Site 1379

Eugene, Oregon, United States

Site Status

Forest Investigative Site 1780

Eugene, Oregon, United States

Site Status

Forest Investigative Site 1108

Hillsboro, Oregon, United States

Site Status

Forest Investigative Site 1294

Portland, Oregon, United States

Site Status

Forest Investigative Site 1109

Bensalem, Pennsylvania, United States

Site Status

Forest Investigative Site 1291

Bensalem, Pennsylvania, United States

Site Status

Forest Investigative Site 1090

Broomall, Pennsylvania, United States

Site Status

Forest Investigative Site 1218

Carnegie, Pennsylvania, United States

Site Status

Forest Investigative Site 1163

Downington, Pennsylvania, United States

Site Status

Forest Investigative Site 1118

Erie, Pennsylvania, United States

Site Status

Forest Investigative Site 1171

Erie, Pennsylvania, United States

Site Status

Forest Investigative Site 1383

Holland, Pennsylvania, United States

Site Status

Forest Investigative Site 1720

Jenkintown, Pennsylvania, United States

Site Status

Forest Investigative Site 1207

Lansdale, Pennsylvania, United States

Site Status

Forest Investigative Site 1314

Norristown, Pennsylvania, United States

Site Status

Forest Investigative Site 1198

Penndel, Pennsylvania, United States

Site Status

Forest Investigative Site 1293

Philadelphia, Pennsylvania, United States

Site Status

Forest Investigative Site 1137

Pittsburgh, Pennsylvania, United States

Site Status

Forest Investigative Site 1247

Red Lion, Pennsylvania, United States

Site Status

Forest Investigative Site 1791

Tipton, Pennsylvania, United States

Site Status

Forest Investigative Site 1196

Upper Saint Clair, Pennsylvania, United States

Site Status

Forest Investigative Site 1172

Warminster, Pennsylvania, United States

Site Status

Forest Investigative Site 1278

West Chester, Pennsylvania, United States

Site Status

Forest Investigative Site 1375

Warwick, Rhode Island, United States

Site Status

Forest Investigative Site 1760

Charleston, South Carolina, United States

Site Status

Forest Investigative Site 1363

Charleston, South Carolina, United States

Site Status

Forest Investigative Site 1122

Columbia, South Carolina, United States

Site Status

Forest Investigative Site 1133

Greenville, South Carolina, United States

Site Status

Forest Investigative Site 1809

Greenville, South Carolina, United States

Site Status

Forest Investigative Site 1327

Greer, South Carolina, United States

Site Status

Forest Investigative Site 1127

Mt. Pleasant, South Carolina, United States

Site Status

Forest Investigative Site 1310

Murrells Inlet, South Carolina, United States

Site Status

Forest Investigative Site 1152

Pelzer, South Carolina, United States

Site Status

Forest Investigative Site 1114

Simpsonville, South Carolina, United States

Site Status

Forest Investigative Site 1149

Spartanburg, South Carolina, United States

Site Status

Forest Investigative Site 1113

Summerville, South Carolina, United States

Site Status

Forest Investigative Site 1806

Union, South Carolina, United States

Site Status

Forest Investigative Site 1185

Dakota Dunes, South Dakota, United States

Site Status

Forest Investigative Site 1753

Rapid City, South Dakota, United States

Site Status

Forest Investigative Site 1402

Bristol, Tennessee, United States

Site Status

Forest Investigative Site 1037

Chattanooga, Tennessee, United States

Site Status

Forest Investigative Site 1031

Clarksville, Tennessee, United States

Site Status

Forest Investigative Site 1074

Collierville, Tennessee, United States

Site Status

Forest Investigative Site 1033

Fayetteville, Tennessee, United States

Site Status

Forest Investigative Site 1763

Kingsport, Tennessee, United States

Site Status

Forest Investigative Site 1744

Knoxville, Tennessee, United States

Site Status

Forest Investigative Site 1358

Memphis, Tennessee, United States

Site Status

Forest Investigative Site 1082

Memphis, Tennessee, United States

Site Status

Forest Investigative Site 1094

Arlington, Texas, United States

Site Status

Forest Investigative Site 1245

Austin, Texas, United States

Site Status

Forest Investigative Site 1311

Austin, Texas, United States

Site Status

Forest Investigative Site 1174

Beaumont, Texas, United States

Site Status

Forest Investigative Site 1762

Boerne, Texas, United States

Site Status

Forest Investigative Site 1244

Bryan, Texas, United States

Site Status

Forest Investigative Site 1776

Carrollton, Texas, United States

Site Status

Forest Investigative Site 1205

Corpus Christi, Texas, United States

Site Status

Forest Investigative Site 1268

Corsicana, Texas, United States

Site Status

Forest Investigative Site 1213

Dallas, Texas, United States

Site Status

Forest Investigative Site 1228

Houston, Texas, United States

Site Status

Forest Investigative Site 1372

Houston, Texas, United States

Site Status

Forest Investigative Site 1777

Houston, Texas, United States

Site Status

Forest Investigative Site 1157

Houston, Texas, United States

Site Status

Forest Investigative Site 1360

Houston, Texas, United States

Site Status

Forest Investigative Site 1230

Houston, Texas, United States

Site Status

Forest Investigative Site 1774

Houston, Texas, United States

Site Status

Forest Investigative Site 1262

Irving, Texas, United States

Site Status

Forest Investigative Site 1229

Longview, Texas, United States

Site Status

Forest Investigative Site 1199

New Braunfels, Texas, United States

Site Status

Forest Investigative Site 1214

Plano, Texas, United States

Site Status

Forest Investigative Site 1129

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1766

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1797

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1295

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1167

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1186

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1257

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1317

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1758

San Antonio, Texas, United States

Site Status

Forest Investigative Site 1334

Sugar Land, Texas, United States

Site Status

Forest Investigative Site 1269

Tomball, Texas, United States

Site Status

Forest Investigative Site 1349

Waco, Texas, United States

Site Status

Forest Investigative Site 1015

Clinton, Utah, United States

Site Status

Forest Investigative Site 1187

Draper, Utah, United States

Site Status

Forest Investigative Site 1226

Draper, Utah, United States

Site Status

Forest Investigative Site 1086

Magna, Utah, United States

Site Status

Forest Investigative Site 1216

Ogden, Utah, United States

Site Status

Forest Investigative Site 1219

Orem, Utah, United States

Site Status

Forest Investigative Site 1328

Riverton, Utah, United States

Site Status

Forest Investigative Site 1771

Salt Lake City, Utah, United States

Site Status

Forest Investigative Site 1175

Salt Lake City, Utah, United States

Site Status

Forest Investigative Site 1197

Salt Lake City, Utah, United States

Site Status

Forest Investigative Site 1194

Salt Lake City, Utah, United States

Site Status

Forest Investigative Site 1202

South Jordan, Utah, United States

Site Status

Forest Investigative Site 1773

St. George, Utah, United States

Site Status

Forest Investigative Site 1786

Arlington, Virginia, United States

Site Status

Forest Investigative Site 1130

Arlington, Virginia, United States

Site Status

Forest Investigative Site 1020

Burke, Virginia, United States

Site Status

Forest Investigative Site 1343

Danville, Virginia, United States

Site Status

Forest Investigative Site 1164

Manassas, Virginia, United States

Site Status

Forest Investigative Site 1767

Norfolk, Virginia, United States

Site Status

Forest Investigative Site 1292

Petersburg, Virginia, United States

Site Status

Forest Investigative Site 1131

Suffolk, Virginia, United States

Site Status

Forest Investigative Site 1099

Virginia Beach, Virginia, United States

Site Status

Forest Investigative Site 1119

Port Orchard, Washington, United States

Site Status

Forest Investigative Site 1394

Seattle, Washington, United States

Site Status

Forest Investigative Site 1085

Spokane, Washington, United States

Site Status

Forest Investigative Site 1335

Walla Walla, Washington, United States

Site Status

Forest Investigative Site 1377

Charleston, West Virginia, United States

Site Status

Forest Investigative Site 1367

Milwaukee, Wisconsin, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

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Giles TD, Weber MA, Basile J, Gradman AH, Bharucha DB, Chen W, Pattathil M; NAC-MD-01 Study Investigators. Efficacy and safety of nebivolol and valsartan as fixed-dose combination in hypertension: a randomised, multicentre study. Lancet. 2014 May 31;383(9932):1889-98. doi: 10.1016/S0140-6736(14)60614-0.

Reference Type DERIVED
PMID: 24881993 (View on PubMed)

Other Identifiers

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NAC-MD-01

Identifier Type: -

Identifier Source: org_study_id

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