Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

22 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-03-31

Study Completion Date

2013-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown to improve orthostatic symptoms in those with spinal cord injury but the physiological mechanisms influenced have not been identified. The investigators will examine key physiological components influencing orthostatic tolerance. The investigators will do this, by measuring the baroreflex, and brain blood flow autoregulation (the ability to maintain brain blood flow) before during and after the sit-up test. Two sit-up tests will occur; one before Midodrine administration, and one after administration of a 10mg dose of Midodrine.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Treatment of Orthostatic Hypotension in SCI

NCT05839652

Hypotension

RECRUITING PHASE4

The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury

NCT02893553

Spinal Cord Injury Autonomic Dysreflexia Baroreceptor Integrity +7 more

COMPLETED PHASE2

Safety and Efficacy of L-NAME and Midodrine to Increase MAP

NCT00835224

Orthostatic Hypotension Spinal Cord Injury

COMPLETED PHASE2

Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury

NCT02307565

Spinal Cord Injury

COMPLETED PHASE3

Treatment of Post-SCI Hypotension

NCT02919917

Spinal Cord Injury Autonomic Dysreflexia Orthostatic Hypotension +7 more

COMPLETED PHASE2/PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Orthostatic Intolerance

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Midodrine

Single 10 mg dose

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Amatine, ProAmatine, Gutron

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* To be included in the study, participants must have sustained a traumatic spinal cord injury within the ages of 18-49 years.
* Also, participants must have an injury level above the 6th thoracic vertebrae and be a non-smoker for a minimum of one year.

Exclusion Criteria

* Any participants with a history of cardiovascular disease, pulmonary disease or diabetes mellitus will not be eligible.
* Also, participants will not be eligible to take part in study if they experiences acute distress, or are taking medications known to influence cardiovascular function.
* Patient will be not eligible for the study if he/she has known adverse reaction to Midodrine.

Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No