A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

139 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-11-30

Study Completion Date

2016-12-31

Brief Summary

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The purpose of this study is to collect biofluid samples for the banking and usage in ALS research. Through comparison of these samples, the researchers hope to learn more about the underlying cause of ALS, as well as find unique biological markers, which could be used to develop new therapies.

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Detailed Description

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The purpose of the research study is to collect blood samples and cerebrospinal fluid (CSF) from people with amyotrophic lateral sclerosis (ALS). These samples will be collected approximately every 4 months.

Conditions

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Amyotrophic Lateral Sclerosis Nervous System Diseases Sclerosis Motor Neuron Disease Spinal Cord Diseases Central Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases ALS

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age 18 or older
* Diagnosis of suspected, possible, probable or definite ALS according to El Escorial Criteria
* Vital capacity (VC) at least 50 percent predicted
* Able to undergo multiple lumbar punctures

Exclusion Criteria

* Abnormal CSF pressure or intracranial/intraspinal tumors
* Use of anticoagulant medication that cannot be safely withheld
* Bleeding disorders

* This is a partial listing.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No