A Prospective Controlled Study of Serum suPAR in the CsA-treated FSGS Patients

NCT ID: NCT01468493

Last Updated: 2017-04-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-31

Study Completion Date

2019-01-31

Brief Summary

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The purpose of this study is to determine whether the improved responsiveness to treatment achieved by CsA in patients with steroid-resistant or steroid-dependent FSGS could be explained by CsA's inhibitory action on the circulating suPAR expression.

Detailed Description

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Conditions

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FSGS

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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steroid-sensitive FSGS

No interventions assigned to this group

steroid-dependent and resistant FSGS

No interventions assigned to this group

Healthy volunteers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age at entry is between 14 and 70 years
* biopsy-proven primary FSGS
* proteinuria \>=3 g/day
* without corticosteroids or CsA treatment before entry

Exclusion Criteria

* Chronic Inflammatory Diseases
* malignant tumor
* diabetes mellitus
* contraindications for the treatment of corticosteroids or CsA treatment
* untolerate to or unwilling to accept corticosteroids or CsA treatment
Minimum Eligible Age

14 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Guangdong Provincial People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wei Shi

Director of renal division of Guangdong General Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Wei Shi, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Nephrology Dept.,Guangdong General Hospital

Locations

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Nephrology Dept.,Guangdong General Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wei Shi, MD,PhD

Role: CONTACT

86-20-8385-0849

Facility Contacts

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Wei Shi, MD,PhD

Role: primary

86-20-8385-0849

Other Identifiers

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GGH-1-1

Identifier Type: -

Identifier Source: org_study_id

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