Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
150 participants
Study Classification
INTERVENTIONAL
Study Start Date
2011-11-30
Study Completion Date
2015-02-28
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Goal directed volume therapy means that bolus doses of 150-250 ml colloid fluid is administered to the patient during contemporary measurement of the patients stroke volume. The fluid status is considered optimized when stroke volume no longer increases with more than 10%, indicating that the patient is close to the top of the Frank-Starling curve. Several studies show that volume optimization reduces hospital stay and reduces the amount of surgical complications. The overall purpose is to investigate if the much more simple non invasive technique Pleth Variability Index can replace oesophageal doppler to guide volume therapy in routine health care, and to analyse if a volume kinetic test can be used to evaluate hypovolemia before surgery and make specific rehydration possible by analysing the correlation between this test and fluid optimization using stroke volume measurements.
Primary hypothesis: 1. The volume of colloids that is given to volume optimise an anesthetized patient using Pleth Variability Index shows a good correlation to the volume used if volume optimisation is undertaken by the guidance of oesophageal doppler. 2. Data from the two methods correlate and discriminates similarly volume responders from non responders. 3. A volume kinetic model that indicates dehydration can predict the need for rehydration in order to achieve a well hydrated patient at start of surgery.
Primary hypothesis: 1. The volume of colloids that is given to volume optimise an anesthetized patient using Pleth Variability Index shows a good correlation to the volume used if volume optimisation is undertaken by the guidance of oesophageal doppler. 2. Data from the two methods correlate and discriminates similarly volume responders from non responders. 3. A volume kinetic model that indicates dehydration can predict the need for rehydration in order to achieve a well hydrated patient at start of surgery.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Traditional Versus Goal Directed Perioperative Fluid Therapy in High Risk Patients
NCT01473446
Postoperative Complications
TERMINATED
NA
Goal-Directed Fluid Therapy in Patients Undergoing Lower Limb Surgeries
NCT06133257
Anesthesia
ERAS
Fluid Overload
+1 more
NOT_YET_RECRUITING
NA
Goal-directed Intraoperative Fluid Therapy in High-risk Surgery
NCT02470221
Postoperative Complications
Fluid Overload
COMPLETED
Hemodynamic Response During Goal Directed Fluid Therapy in the OR
NCT02365688
Hemodynamic Instability
TERMINATED
NA
Decreasing Postoperative Complications by Goal-Directed Fluid Therapy During Esophageal Resection
NCT01416077
Esophageal Cancer
COMPLETED
PHASE4
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The patients are not allowed to eat after midnight. Routine premedication is given with paracetamol and oxynorm/oxycontin. Thrombosis and antibiotic prophylaxis is given according to surgical department.
The weight of the patient is notices on the morning of surgery (day 0).
The patient arrives in the morning to the preoperative area. A urinary analysis is taken for urinary colour, creatinine, specific weight, osmolality, microalbuminuria and electrolytes. For 30 patients a volume kinetic analysis of 5 ml/kg infusion of acetated Ringers solution is undertaken between 6.30 and 8.00 am on the morning of surgery. During 15 minutes 5 ml/kg acetated Ringers solution is infused intravenously. Hb is continuously measured noninvasively by Masimo Radical 7 pulse oximeter (MasimoHb) and invasively with maximum 13 samples a 4 ml during 80 minutes (0, 10, 15, 25, 40, 50, 60 and 70 min. Double samples at start and 60 min. The volume kinetic part of the study is finished after 70 min when the patient urinates and the volume is measured.
The patient is taken to the operating theatre and MasimoHb, NT-proBNP, Troponin T hs, pl-lactate, PI och PVI (stable value during 5 min) is registered before anaesthesia. Avoid having blood pressure cuff and pulse oximeter for PVI analysis on the same arm. Aim at PI \> 1 to get a reliable registration of PVI, otherwise try another finger.
Anaesthesia: Epidural anaesthesia according to clinical praxis (activated after the first volume optimisation and kept activated during surgery) and anaesthesia according to clinical practise. The ventilation during anaesthesia is maintained using volume controlled mode, tidal volume 7 ml/kg (ideal weight, using the formula: men 50 + 0.91(height in centimetre -152.4); women 45.5 + 0.91(height in centimetre -152.4)), PEEP 5 - 10 cmH2O, respiratory rate to achieve normocapnia. Tidal volume and PEEP is maintained during surgery. The Doppler sond is placed after anaesthesia induction and after that the gastric sond is placed.
During induction of anaesthesia an amount of u to 500 ml colloid solution as well as intermittently ephedrine in small doses of 2.5 - 10 mg can be given for circulatory stability.
Antibiotics are given according to clinical practice.
Preoperative fluid regimen:
Grupp OD:
Basic infusion: Buffered glucose 2.5% 1000 ml 2 ml/kg/h. The first volume optimization of stroke volume (SV) takes place after anaesthesia induction and a stable baseline of measurement is achieved. Note SV (mean value during 1 min), Flow time corrected (FTC), MasimoHb and PVI (mean value during 1 min). The PVI value is only visualised to the research nurse and not to the attending anaesthesiologist. Administer 3 ml/kg (actual weight) maximum 250 ml hydroxyethyl starch during 5 minutes. Wait for 5 minutes. Note SV, FTC, MasimoHb and PVI. If SV increases more than 10 % a new colloid bolus is given. This is repeated in cycles until SV not increases \> 10%, or DO2i \> 600 ml/min/m2. For every cycle SV, FTC, MasimoHb and PVI are noted. The first optimization is undertaken before start of surgery.
SV, FTC, MasimoHb and PVI are followed during surgery. If SV is reduced \> 10% from the value after the last bolus dose a new volume optimization is repeated as described above.
If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma. Bolus doses of albumin 4% and plasma are also 3 ml/kg with a maximum of 250 ml.
Beside infusion of colloids, acetated Ringers solution 0-1000 ml can be given according to the decision from the attending anaesthesiologist.
Blood loss is replaced ml by ml with colloid until Hb 90 g/l (100 if the patient has an ischemic heart disease or any other condition at the discretion from the attending anaesthesiologist). Thereafter replacement is given1:1 using SAG and colloid/albumin/plasma. If blood loss exceeds half the blood volume replacement is given only using SAG/plasma. Thrombocytes are given according to clinical practice.
Any use of inotropic and vasoactive drugs is documented.
At the end of surgery pl-lactate and Hb is measured invasively and non-invasively (HB). Estimated blood loss is registered.
Grupp PVI:
Basic infusion: Buffered glucose 2.5% 1000 ml 2 ml/kg/h.
The first volume optimization of stroke volume (SV) takes place after anaesthesia induction and a stable baseline of measurement is achieved. Note PVI ( mean value during 1 min), MasimoHb, SV (mean value during 1 min) and Flow time corrected (FTC). Data from the oesophagus doppler is only visualised to the research nurse and not to the attending anaesthesiologist. Administer 3 ml/kg (actual weight) maximum 250 ml hydroxyethyl starch during 5 minutes. Wait for 5 minutes. Note SV, FTC, MasimoHb and PVI. If PVI is \>10 % and reduced give a new colloid bolus. For every cycle SV, FTC, MasimoHb and PVI are noted. The first optimization is undertaken before start of surgery.
If PVI \>10 % the volume optimization is repeated as described above. If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma. Bolus doses of albumin 4% and plasma are also 3 ml/kg with a maximum of 250 ml.
Beside infusion of colloids, acetated Ringers solution 0-1000 ml can be given according to the decision from the attending anaesthesiologist.
Blood loss is replaced ml by ml with colloid until Hb 90 g/l (100 if the patient has an ischemic heart disease or any other condition at the discretion from the attending anaesthesiologist). Thereafter replacement is given1:1 using SAG and colloid/albumin/plasma. If blood loss exceeds half the blood volume replacement is given only using SAG/plasma. Thrombocytes are given according to clinical practice.
Any use of inotropic and vasoactive drugs is documented.
At the end of surgery pl-lactate and Hb is measured invasively and non invasively (HB). Estimated blood loss is registered.
Both groups: If the patients' perioperative course demands that the anaesthesiologists in charge deviate from the study protocol the reason for this is registered in the CRF.
All patients have a urinary bladder catheter or cystofix as decided by the surgeon. The temperature of the patient is measured. Hot air blanked is used to prevent hypothermia.
Post-operatively after 12-24 hours and 36-48 hours pl-NT-proBNP and pl-troponinThs are measured.
The patients weight is registered the morning on the day after surgery (day 1).
Date for end of hospital stay is registered.
A blinded team registers postoperative complications on the 3d day after surgery according to a preset protocol. The record is also reviewed retrospectively to document all complications during the first 30 days after surgery.
For patients 1-75 Doppler and PVI are recorded simultaneously to allow analysis of concordance between PVI and Doppler as guide to fluid optimization. Also biochemical analyses of cardiac enzymes as part of the study are undertaken in patients 1-75. For patients 1-150 the outcome measure postoperative complications is registered.
The weight of the patient is notices on the morning of surgery (day 0).
The patient arrives in the morning to the preoperative area. A urinary analysis is taken for urinary colour, creatinine, specific weight, osmolality, microalbuminuria and electrolytes. For 30 patients a volume kinetic analysis of 5 ml/kg infusion of acetated Ringers solution is undertaken between 6.30 and 8.00 am on the morning of surgery. During 15 minutes 5 ml/kg acetated Ringers solution is infused intravenously. Hb is continuously measured noninvasively by Masimo Radical 7 pulse oximeter (MasimoHb) and invasively with maximum 13 samples a 4 ml during 80 minutes (0, 10, 15, 25, 40, 50, 60 and 70 min. Double samples at start and 60 min. The volume kinetic part of the study is finished after 70 min when the patient urinates and the volume is measured.
The patient is taken to the operating theatre and MasimoHb, NT-proBNP, Troponin T hs, pl-lactate, PI och PVI (stable value during 5 min) is registered before anaesthesia. Avoid having blood pressure cuff and pulse oximeter for PVI analysis on the same arm. Aim at PI \> 1 to get a reliable registration of PVI, otherwise try another finger.
Anaesthesia: Epidural anaesthesia according to clinical praxis (activated after the first volume optimisation and kept activated during surgery) and anaesthesia according to clinical practise. The ventilation during anaesthesia is maintained using volume controlled mode, tidal volume 7 ml/kg (ideal weight, using the formula: men 50 + 0.91(height in centimetre -152.4); women 45.5 + 0.91(height in centimetre -152.4)), PEEP 5 - 10 cmH2O, respiratory rate to achieve normocapnia. Tidal volume and PEEP is maintained during surgery. The Doppler sond is placed after anaesthesia induction and after that the gastric sond is placed.
During induction of anaesthesia an amount of u to 500 ml colloid solution as well as intermittently ephedrine in small doses of 2.5 - 10 mg can be given for circulatory stability.
Antibiotics are given according to clinical practice.
Preoperative fluid regimen:
Grupp OD:
Basic infusion: Buffered glucose 2.5% 1000 ml 2 ml/kg/h. The first volume optimization of stroke volume (SV) takes place after anaesthesia induction and a stable baseline of measurement is achieved. Note SV (mean value during 1 min), Flow time corrected (FTC), MasimoHb and PVI (mean value during 1 min). The PVI value is only visualised to the research nurse and not to the attending anaesthesiologist. Administer 3 ml/kg (actual weight) maximum 250 ml hydroxyethyl starch during 5 minutes. Wait for 5 minutes. Note SV, FTC, MasimoHb and PVI. If SV increases more than 10 % a new colloid bolus is given. This is repeated in cycles until SV not increases \> 10%, or DO2i \> 600 ml/min/m2. For every cycle SV, FTC, MasimoHb and PVI are noted. The first optimization is undertaken before start of surgery.
SV, FTC, MasimoHb and PVI are followed during surgery. If SV is reduced \> 10% from the value after the last bolus dose a new volume optimization is repeated as described above.
If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma. Bolus doses of albumin 4% and plasma are also 3 ml/kg with a maximum of 250 ml.
Beside infusion of colloids, acetated Ringers solution 0-1000 ml can be given according to the decision from the attending anaesthesiologist.
Blood loss is replaced ml by ml with colloid until Hb 90 g/l (100 if the patient has an ischemic heart disease or any other condition at the discretion from the attending anaesthesiologist). Thereafter replacement is given1:1 using SAG and colloid/albumin/plasma. If blood loss exceeds half the blood volume replacement is given only using SAG/plasma. Thrombocytes are given according to clinical practice.
Any use of inotropic and vasoactive drugs is documented.
At the end of surgery pl-lactate and Hb is measured invasively and non-invasively (HB). Estimated blood loss is registered.
Grupp PVI:
Basic infusion: Buffered glucose 2.5% 1000 ml 2 ml/kg/h.
The first volume optimization of stroke volume (SV) takes place after anaesthesia induction and a stable baseline of measurement is achieved. Note PVI ( mean value during 1 min), MasimoHb, SV (mean value during 1 min) and Flow time corrected (FTC). Data from the oesophagus doppler is only visualised to the research nurse and not to the attending anaesthesiologist. Administer 3 ml/kg (actual weight) maximum 250 ml hydroxyethyl starch during 5 minutes. Wait for 5 minutes. Note SV, FTC, MasimoHb and PVI. If PVI is \>10 % and reduced give a new colloid bolus. For every cycle SV, FTC, MasimoHb and PVI are noted. The first optimization is undertaken before start of surgery.
If PVI \>10 % the volume optimization is repeated as described above. If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma. Bolus doses of albumin 4% and plasma are also 3 ml/kg with a maximum of 250 ml.
Beside infusion of colloids, acetated Ringers solution 0-1000 ml can be given according to the decision from the attending anaesthesiologist.
Blood loss is replaced ml by ml with colloid until Hb 90 g/l (100 if the patient has an ischemic heart disease or any other condition at the discretion from the attending anaesthesiologist). Thereafter replacement is given1:1 using SAG and colloid/albumin/plasma. If blood loss exceeds half the blood volume replacement is given only using SAG/plasma. Thrombocytes are given according to clinical practice.
Any use of inotropic and vasoactive drugs is documented.
At the end of surgery pl-lactate and Hb is measured invasively and non invasively (HB). Estimated blood loss is registered.
Both groups: If the patients' perioperative course demands that the anaesthesiologists in charge deviate from the study protocol the reason for this is registered in the CRF.
All patients have a urinary bladder catheter or cystofix as decided by the surgeon. The temperature of the patient is measured. Hot air blanked is used to prevent hypothermia.
Post-operatively after 12-24 hours and 36-48 hours pl-NT-proBNP and pl-troponinThs are measured.
The patients weight is registered the morning on the day after surgery (day 1).
Date for end of hospital stay is registered.
A blinded team registers postoperative complications on the 3d day after surgery according to a preset protocol. The record is also reviewed retrospectively to document all complications during the first 30 days after surgery.
For patients 1-75 Doppler and PVI are recorded simultaneously to allow analysis of concordance between PVI and Doppler as guide to fluid optimization. Also biochemical analyses of cardiac enzymes as part of the study are undertaken in patients 1-75. For patients 1-150 the outcome measure postoperative complications is registered.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Postoperative Complications
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
SINGLE
Outcome Assessors
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Oesophageal Doppler (OD)
Goal directed volume therapy is most often guided by stroke volume measurements by OD.
Group Type
ACTIVE_COMPARATOR
Volume of colloid infusion
Intervention Type
OTHER
Colloid infusion is primarily given as hydroxyethyl starch 60 mg/ml. If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma.
Pleth Variability Index (PVI)
The Pleth variability index (PVI) is an automated function in pulse oximetry that continuously calculates the dynamic variation between the pulse oximetry pulse variation and its baseline for every breathing circuit. Dynamic indicators are advantageous in predicting a responder to a volume bolus, thus facilitating goal directed volume therapy.
Group Type
ACTIVE_COMPARATOR
Volume of colloid infusion
Intervention Type
OTHER
Colloid infusion is given primarily as hydroxyethyl starch 60 mg/ml. If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Volume of colloid infusion
Colloid infusion is primarily given as hydroxyethyl starch 60 mg/ml. If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma.
Intervention Type
OTHER
Volume of colloid infusion
Colloid infusion is given primarily as hydroxyethyl starch 60 mg/ml. If more than 30 ml/kg hydroxyethyl starch 60 mg/ml is given, colloid solution is changed to albumin 4% or plasma.
Intervention Type
OTHER
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
1. Open abdominal surgery under general anaesthesia with a planned operation time of at least 120 minutes
2. Age ≥ 18 years
2. Age ≥ 18 years
Exclusion Criteria
1. Anaesthesia risk classification ASA ≥ 4
2. Arrhythmia; atrial fibrillation or multiple extra systoles
3. Aortic - or mitral insufficiency with hemodynamic influence
4. Patients who at the preoperative visit by the responsible anaesthesiologist is planned for a more advanced cardiovascular monitoring. The following monitoring is accepted in the study: invasive blood pressure, 5-lead ECG, central venous pressure and urinary output per hour.
5. Patients with a pulmonary or other disease that prevents ventilation using a tidal volume of 7 ml/kg (ideal weight) or a positive end expiratory pressure of 5 -10 cm H2O
6. Contra indication against synthetic colloids as severely impaired renal or liver function, hyper natremia or allergy to synthetic colloids
7. Laparoscopic surgery
8. Liver surgery
9. Surgery including thoracotomy
10. Contraindications against an oesophageal probe such as severe oesophageal varicose veins
2. Arrhythmia; atrial fibrillation or multiple extra systoles
3. Aortic - or mitral insufficiency with hemodynamic influence
4. Patients who at the preoperative visit by the responsible anaesthesiologist is planned for a more advanced cardiovascular monitoring. The following monitoring is accepted in the study: invasive blood pressure, 5-lead ECG, central venous pressure and urinary output per hour.
5. Patients with a pulmonary or other disease that prevents ventilation using a tidal volume of 7 ml/kg (ideal weight) or a positive end expiratory pressure of 5 -10 cm H2O
6. Contra indication against synthetic colloids as severely impaired renal or liver function, hyper natremia or allergy to synthetic colloids
7. Laparoscopic surgery
8. Liver surgery
9. Surgery including thoracotomy
10. Contraindications against an oesophageal probe such as severe oesophageal varicose veins
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Lena Nilsson
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Lena Nilsson
Senior consultant, PhD
Responsibility Role
SPONSOR_INVESTIGATOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Lena Nilsson, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Anestesi- och operationskliniken, Universitetssjukuset, SE 58183 Linköping, Sweden
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Anestesi-och operationskliniken
Linköping, , Sweden
Site Status
Countries
Review the countries where the study has at least one active or historical site.
Sweden
References
Explore related publications, articles, or registry entries linked to this study.
Brandstrup B, Tonnesen H, Beier-Holgersen R, Hjortso E, Ording H, Lindorff-Larsen K, Rasmussen MS, Lanng C, Wallin L, Iversen LH, Gramkow CS, Okholm M, Blemmer T, Svendsen PE, Rottensten HH, Thage B, Riis J, Jeppesen IS, Teilum D, Christensen AM, Graungaard B, Pott F; Danish Study Group on Perioperative Fluid Therapy. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg. 2003 Nov;238(5):641-8. doi: 10.1097/01.sla.0000094387.50865.23.
Reference Type
BACKGROUND
Abbas SM, Hill AG. Systematic review of the literature for the use of oesophageal Doppler monitor for fluid replacement in major abdominal surgery. Anaesthesia. 2008 Jan;63(1):44-51. doi: 10.1111/j.1365-2044.2007.05233.x.
Reference Type
BACKGROUND
Cannesson M, Desebbe O, Rosamel P, Delannoy B, Robin J, Bastien O, Lehot JJ. Pleth variability index to monitor the respiratory variations in the pulse oximeter plethysmographic waveform amplitude and predict fluid responsiveness in the operating theatre. Br J Anaesth. 2008 Aug;101(2):200-6. doi: 10.1093/bja/aen133. Epub 2008 Jun 2.
Reference Type
BACKGROUND
Gan TJ, Soppitt A, Maroof M, el-Moalem H, Robertson KM, Moretti E, Dwane P, Glass PS. Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology. 2002 Oct;97(4):820-6. doi: 10.1097/00000542-200210000-00012.
Reference Type
BACKGROUND
Svensen CH, Olsson J, Hahn RG. Intravascular fluid administration and hemodynamic performance during open abdominal surgery. Anesth Analg. 2006 Sep;103(3):671-6. doi: 10.1213/01.ane.0000226092.48770.fe.
Reference Type
BACKGROUND
Hahn RG. Detection of low urine output by measuring urinary biomarkers. BMC Nutr. 2024 Jan 12;10(1):13. doi: 10.1186/s40795-024-00823-3.
Reference Type
DERIVED
Hahn RG, Wuethrich PY, Zdolsek JH. Can perioperative hemodilution be monitored with non-invasive measurement of blood hemoglobin? BMC Anesthesiol. 2021 May 6;21(1):138. doi: 10.1186/s12871-021-01351-4.
Reference Type
DERIVED
Bahlmann H, Hahn RG, Nilsson L. Pleth variability index or stroke volume optimization during open abdominal surgery: a randomized controlled trial. BMC Anesthesiol. 2018 Aug 18;18(1):115. doi: 10.1186/s12871-018-0579-4.
Reference Type
DERIVED
Hahn RG, Bahlmann H, Nilsson L. Preoperative fluid retention increases blood loss during major open abdominal surgery. Perioper Med (Lond). 2017 Sep 2;6:12. doi: 10.1186/s13741-017-0068-1. eCollection 2017.
Reference Type
DERIVED
Hahn RG, Bahlmann H, Nilsson L. Dehydration and fluid volume kinetics before major open abdominal surgery. Acta Anaesthesiol Scand. 2014 Nov;58(10):1258-66. doi: 10.1111/aas.12416.
Reference Type
DERIVED
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
PVI vers OD
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Risk Stratification and Goal-directed Volume Therapy
NCT01456702
UNKNOWN
NA
Effect of Goal-directed Fluid Therapy Using Stroke Volume Variation in Patients Undergoing Free Flap Reconstruction After Head and Neck Cancer Resection
NCT02003066
COMPLETED
NA
Perioperative Fluid Therapy in Patients Undergoing Pancreaticoduodenectomy
NCT04687826
COMPLETED
The Effect of Fluid Management by SVV of FloTrac/ Vigileo™ Monitoring on Postoperative Recovery in Bowel Resection
NCT02288767
COMPLETED
NA
Goal Directed Therapy for Patients Undergoing Major Vascular Surgery
NCT01681251
COMPLETED
PHASE1
the Effects of Perioperative Goal Directed and Conventional Fluid Management on the IVC Collapsibility Index
NCT05154435
COMPLETED
NA
The Effect of Intraoperative Goal Directed Restricted Fluid Therapy on Extravascular Lung Water
NCT02845310
COMPLETED
NA
Effect of Goal-directed Fluid Therapy Based on Stroke Volume Variation on Metabolic Acidosis in Patients Undergoing Brain Tumor Surgery
NCT01738880
COMPLETED
NA
Traditional Versus ScvO2 Guided Perioperative Fluid Therapy
NCT00468793
COMPLETED
PHASE4
Preoperative Goal-directed Fluid Therapy and Physiological Changes Following One-lung Ventilation
NCT03064880
UNKNOWN
NA
REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery
NCT02073162
COMPLETED
NA
Restrictive or Doppler-guided Fluid Treatment in Colorectal Surgery
NCT03677622
COMPLETED
NA
Comparison of Goal-directed and Liberal Fluid Management
NCT04265014
WITHDRAWN
NA
Restrictive vs Goal Directed Fluid Therapy During Hepatobiliary Surgery
NCT04092608
COMPLETED
NA
Intraoperative Hypovolemia and Fluid Therapy
NCT00852449
TERMINATED
PHASE4
Goal Directed Fluid Therapy in Free Flap Patients
NCT00869297
COMPLETED
NA
The Stroke Volume Optimization of Goal Directed Fluid Therapy During Radical Cystectomy
NCT03262480
COMPLETED
NA
Prediction Model of the Blood Pressure Response to the Administration of Fluids in Abdominal Surgery Using the Pram Method.
NCT04594174
UNKNOWN
Effect of SVV Guided Fluid Therapy on Blood Loss and Postoperative Outcomes
NCT02373735
COMPLETED
NA
Comparison of Perioperative Standard Fluid Management and Goal-Directed Fluid Management
NCT04728178
COMPLETED
NA
Restrictive- vs Individualized Goal Directed Fluid Therapy in Liver Surgery
NCT05704387
COMPLETED
NA
Goal Directed Fluid Therapy in Free Flap Reconstructive Surgery
NCT01129037
COMPLETED
NA
Goal Directed Fluid Therapy Guided Fluid Management in Pneumoresection
NCT03237351
COMPLETED
NA
Comparison of PVI-guided Fluid Management With Traditional Fluid Management in Colorectal Surgery
NCT03339895
COMPLETED
NA
Evaluation of Goal-Directed Intraoperative Hemodynamic Optimization Protocol
NCT02057653
COMPLETED