Metabolomic Embryo Profiles of Obese in Vitro Fertilization (IVF) Patients and Their Relationship With Polycystic Ovary Syndrome (PCO)
NCT ID: NCT01448863
Last Updated: 2015-03-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
28 participants
OBSERVATIONAL
2011-10-31
2014-10-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
NCT03998553
Targeted Metabolomics and Spent Embryo Culture Medium
NCT06094439
Second Phase of the Pilot Study for Obtaining Mature Oocytes by in Vitro Maturation in Oocyte-donor Women
NCT06103383
Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome
NCT01841528
In Vitro Maturation of Immature Oocytes
NCT00480337
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
CASE_CONTROL
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
CONTROL
Fertile women (egg-donors)
Culture medium metabolomic analysis
During the embryo transfer at day 3, the investigators keep and freeze a small drop of the culture medium of each embryo transferred. Each drop of culture medium will have a volume of 40-50 microliters, before freezing is spun at 10.000 rps to avoid any possible contamination.
The frozen media culture is analyzed for the metabolomic profile.
WITH PCO
Obese women with Polycystic Ovarian Syndrome
Culture medium metabolomic analysis
During the embryo transfer at day 3, the investigators keep and freeze a small drop of the culture medium of each embryo transferred. Each drop of culture medium will have a volume of 40-50 microliters, before freezing is spun at 10.000 rps to avoid any possible contamination.
The frozen media culture is analyzed for the metabolomic profile.
NO PCO
Obese women without Polycystic Ovarian Syndrome
Culture medium metabolomic analysis
During the embryo transfer at day 3, the investigators keep and freeze a small drop of the culture medium of each embryo transferred. Each drop of culture medium will have a volume of 40-50 microliters, before freezing is spun at 10.000 rps to avoid any possible contamination.
The frozen media culture is analyzed for the metabolomic profile.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Culture medium metabolomic analysis
During the embryo transfer at day 3, the investigators keep and freeze a small drop of the culture medium of each embryo transferred. Each drop of culture medium will have a volume of 40-50 microliters, before freezing is spun at 10.000 rps to avoid any possible contamination.
The frozen media culture is analyzed for the metabolomic profile.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Age \< 38 years old
* Non smokers
* First IVF cycle (groups 2 \& 3, not Control group)
* Normal uterus (seen by ultrasound)
* normal basal hormonal profile(FSH,LH,estradiol,testosterone,androstenedione, insulin, SHBG, glucose, AMH)
* Antral follicle count(\> 5 FA for each ovary)
* Menses every 25-35 days.
Exclusion Criteria
* estradiol \>3000 pg/ml or progesterone \> 1,5 ng/ml on the hCG day.
* \< 2 evolutive embryos in the culture medium.
18 Years
38 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Instituto Valenciano de Infertilidad, IVI VALENCIA
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Jose Bellver
Gynecologist IVI Valencia
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
IVI Valencia
Valencia, Valencia, Spain
IVI Valencia
Valencia, , Spain
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Bellver J, De Los Santos MJ, Alama P, Castello D, Privitera L, Galliano D, Labarta E, Vidal C, Pellicer A, Dominguez F. Day-3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization. Fertil Steril. 2015 Jun;103(6):1407-15.e1. doi: 10.1016/j.fertnstert.2015.03.015. Epub 2015 Apr 29.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
1005-C-070-JB
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.