VH-IVUS Plaque Composition Analysis By Fractional Flow Reserve

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-03-31

Study Completion Date

2014-12-31

Brief Summary

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Recent clinical trials demonstrated that virtual histology-intravascular ultrasound (VH-IVUS) is a useful test predicting clinical outcomes of the coronary artery disease (CAD). Thin cap fibroatheroma (VH-TCFA) was proposed a predictor of cardiovascular event by VH-IVUS combined with more than 70% plaque burden and less than 4mm² minimal lumen area (MLA) by IVUS. Fractional flow reserve (FFR) is an established index of the physiological significance of a coronary stenosis. Recent large scale trials demonstrated FFR guided PCI showed favorable clinical outcomes. VH-IVUS represents anatomical severity, but FFR represents functional severity of CAD. Few studies reported relevance between two tests. Aim of this study was to investigate whether the geometry and composition of lesions were different under FFR criteria.

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Detailed Description

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Conditions

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Coronary Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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low FFR group (<0.8)

the patient with FFR values less than 0.8

No interventions assigned to this group

high FFR group (>0.8)

the patient with FFR values greater than 0.8

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* clinical angina pectoris who underwent VH-IVUS and FFR during coronary angiography.
* agree with informed consent

Exclusion Criteria

* unable to get informed consent
* low left ventricular ejection fraction less than 35%
* chronic renal failure (Cr\>2.0mg/dl)
* acute myocardial infarction related coronary artery
* allergy to adenosine injection

Minimum Eligible Age

20 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No