Efficacy and Safety of Irbesartan and Atorvastatin in Hypertension and Hyperlipidemia

NCT ID: NCT01442987

Last Updated: 2013-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

230 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2013-05-31

Brief Summary

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The purpose of this study is to evaluate efficacy and safety of coadministered Irbesartan and Atorvastatin in patients with hypertension and hyperlipidemia.

Detailed Description

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Conditions

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Hypertension Hyperlipidemia

Keywords

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Irbesartan Atorvastatin Hypertension Hyperlipidemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Irbesartan/Atorvastatin A

Group Type EXPERIMENTAL

Irbesartan/Atorvastatin A

Intervention Type DRUG

once daily, P.O. 8week

Irbesartan

Group Type ACTIVE_COMPARATOR

Irbesartan

Intervention Type DRUG

once daily, P.O. 8week

Atorvastatin A

Group Type ACTIVE_COMPARATOR

Atorvastatin A

Intervention Type DRUG

once daily, P.O. 8week

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

once daily, P.O. 8week

Irbesartan/Atorvastatin B

Group Type EXPERIMENTAL

Irbesartan/Atorvastatin B

Intervention Type DRUG

once daily, P.O. 8week

Atorvastatin B

Group Type ACTIVE_COMPARATOR

Atorvastatin B

Intervention Type DRUG

once daily, P.O. 8week

Interventions

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Irbesartan/Atorvastatin A

once daily, P.O. 8week

Intervention Type DRUG

Irbesartan

once daily, P.O. 8week

Intervention Type DRUG

Atorvastatin A

once daily, P.O. 8week

Intervention Type DRUG

Placebo

once daily, P.O. 8week

Intervention Type DRUG

Irbesartan/Atorvastatin B

once daily, P.O. 8week

Intervention Type DRUG

Atorvastatin B

once daily, P.O. 8week

Intervention Type DRUG

Other Intervention Names

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HCP0912 A HCP0912 B

Eligibility Criteria

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Inclusion Criteria

* Aged between 19 and 75 years
* Signed informed consent

Exclusion Criteria

* At screening, SPB ≥ 180mmHg or DBP ≥ 110mmHg or LDL-C \> 250mg/dL or TG ≥ 400mg/dL
* Has a history of hypersensitivity to Angiotensin Ⅱ receptor blocker or HMG-CoA reductase inhibitor or component of this drug
* Has a history of multi-drug allergy
Minimum Eligible Age

19 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hanmi Pharmaceutical Company Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Byeong Hee Oh, M.D

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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16 institutions including Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Kim SH, Jo SH, Lee SC, Lee SY, Yoon MH, Lee HL, Lee NH, Ha JW, Lee NH, Kim DW, Han GR, Hyon MS, Cho DG, Park CG, Kim YD, Ryu GH, Kim CH, Kim KS, Chung MH, Chae SC, Seung KB, Oh BH. Blood Pressure and Cholesterol-lowering Efficacy of a Fixed-dose Combination With Irbesartan and Atorvastatin in Patients With Hypertension and Hypercholesterolemia: A Randomized, Double-blind, Factorial, Multicenter Phase III Study. Clin Ther. 2016 Oct;38(10):2171-2184. doi: 10.1016/j.clinthera.2016.09.005. Epub 2016 Oct 12.

Reference Type DERIVED
PMID: 27742464 (View on PubMed)

Other Identifiers

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HM-IBAT-301

Identifier Type: -

Identifier Source: org_study_id