Cellular and Molecular Mechanisms Governing Bone Marrow Stem Cells in Gaucher Disease
NCT ID: NCT01439607
Last Updated: 2014-05-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2009-12-31
2012-03-31
Brief Summary
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Detailed Description
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In this project, the investigators aimed to study the cellular and molecular mechanisms governing the biology of various cell populations of the bone marrow and blood in these patients in order to define their potential role in the physiopathology of the disease. The main research topics the investigators plan will then be focused on characterization and functional analysis of hematopoietic stem cells, mesenchymal stem cells (with a special focus on osteogenic differentiation), macrophages and osteoclastic differentiation, B lymphocytes and plasma cells.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Bone marrow and blood sampling
Bone marrow and blood sampling
Bone marrow and blood sampling
Interventions
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Bone marrow and blood sampling
Bone marrow and blood sampling
Eligibility Criteria
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Inclusion Criteria
* Gaucher disease
* clinical examination written consent
Exclusion Criteria
* HIV seropositive
* contraindication to bone marrow sampling
18 Years
ALL
No
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Bertrabd Arnulf, MD
Role: PRINCIPAL_INVESTIGATOR
Assistance Publique - Hôpitaux de Paris
Locations
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Bertrand Arnulf
Paris, Paris, France
Countries
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Other Identifiers
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P081102
Identifier Type: -
Identifier Source: org_study_id
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