A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular Epinephrine
NCT ID: NCT01432522
Last Updated: 2011-09-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2010-07-31
2011-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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epinephrine IN, epinephrine IM, saline IN
1. Intranasal saline
2. Intramuscular epinephrine
3. Intranasal epinephrine
Epinephrine
1. Intranasal epinephrine 5 mg /spray
2. Intramuscular epinephrine 0.3 mg
3. Intranasal saline spray
Interventions
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Epinephrine
1. Intranasal epinephrine 5 mg /spray
2. Intramuscular epinephrine 0.3 mg
3. Intranasal saline spray
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. 18-30 years-old
Exclusion Criteria
2. Subjected who use current medication that interfere with result of plasma epinephrine level such as pseudoephedrine
18 Years
30 Years
ALL
Yes
Sponsors
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Mahidol University
OTHER
Siriraj Hospital
OTHER
Responsible Party
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Pakit Vichyanond, MD
Professor of Pediatrics
Principal Investigators
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Pakit Vichyanond, MD.
Role: STUDY_DIRECTOR
Siriraj medical school, Mahidol Univrsity
Locations
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Facaulty of Medicine, Siriraj Hospital
Bangkok, Bangkok, Thailand
Countries
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References
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Simons FE, Gu X, Simons KJ. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol. 2001 Nov;108(5):871-3. doi: 10.1067/mai.2001.119409.
Rawas-Qalaji MM, Simons FE, Simons KJ. Sublingual epinephrine tablets versus intramuscular injection of epinephrine: dose equivalence for potential treatment of anaphylaxis. J Allergy Clin Immunol. 2006 Feb;117(2):398-403. doi: 10.1016/j.jaci.2005.12.1310.
Simons FE, Gu X, Johnston LM, Simons KJ. Can epinephrine inhalations be substituted for epinephrine injection in children at risk for systemic anaphylaxis? Pediatrics. 2000 Nov;106(5):1040-4. doi: 10.1542/peds.106.5.1040.
Heilborn H, Hjemdahl P, Daleskog M, Adamsson U. Comparison of subcutaneous injection and high-dose inhalation of epinephrine--implications for self-treatment to prevent anaphylaxis. J Allergy Clin Immunol. 1986 Dec;78(6):1174-9. doi: 10.1016/0091-6749(86)90268-x.
Other Identifiers
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078/2550
Identifier Type: -
Identifier Source: org_study_id
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