A Double-blind, Double-dummy, Parallel, Active-controlled, Randomized Trial to Evaluate Efficacy & Safety in Anemia Subjects

NCT ID: NCT01425463

Last Updated: 2015-06-01

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

256 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2013-11-30

Brief Summary

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To evaluate the efficacy and safety of 12 weeks treatment with Ferrous (II) Glycine Sulphate Complex in comparison to Polyferose capsules in Chinese subjects with manifest Iron Deficiency Anemia.

Detailed Description

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Conditions

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Iron Deficiency Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Ferrous (II) Glycine Sulphate Complex

Ferrous (II) Glycine Sulphate Complex treatment with 567.7 mg three times a day (t.i.d.) for 12 weeks plus Placebo to Polyferose.

Group Type EXPERIMENTAL

Ferrous (II) Glycine Sulphate Complex

Intervention Type DRUG

Oral dose of 567.7 mg Ferrous (II) Glycine Sulphate Complex three times a day (t.i.d) for 12 weeks (equivalent to 300 mg iron element per day for 12 weeks).

Administered orally with water.

Placebo to Polyferose

Intervention Type OTHER

Administered orally with water.

Polyferose

Polyferose treatment with 150 mg twice daily (b.i.d) for 12 weeks plus Placebo to Ferrous (II) Glycine Sulphate Complex.

Group Type ACTIVE_COMPARATOR

Polyferose

Intervention Type DRUG

Oral dose of 150 mg Polyferose Capsules twice daily (b.i.d) for 12 weeks (equivalent to 300 mg iron element per day for 12 weeks).

Administered orally with water.

Placebo to Ferrous (II) Glycine Sulphate Complex

Intervention Type OTHER

Administered orally with water.

Interventions

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Ferrous (II) Glycine Sulphate Complex

Oral dose of 567.7 mg Ferrous (II) Glycine Sulphate Complex three times a day (t.i.d) for 12 weeks (equivalent to 300 mg iron element per day for 12 weeks).

Administered orally with water.

Intervention Type DRUG

Polyferose

Oral dose of 150 mg Polyferose Capsules twice daily (b.i.d) for 12 weeks (equivalent to 300 mg iron element per day for 12 weeks).

Administered orally with water.

Intervention Type DRUG

Placebo to Ferrous (II) Glycine Sulphate Complex

Administered orally with water.

Intervention Type OTHER

Placebo to Polyferose

Administered orally with water.

Intervention Type OTHER

Other Intervention Names

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Ferro Sanol Duodenal Nifirex

Eligibility Criteria

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Inclusion Criteria

* An iron deficiency anemia patient with Serum Ferritin \< 12 ng/mL, serum Hb-values \>60 and \< 120 g/L in males, \< 110 g/L in females

Exclusion Criteria

* With any Mal-absorption Syndrome
* With a history of Thalassemia or Sickle Cell Anemia
* With untreated concurrent Vitamin B12 or Folate deficiency at Baseline
Minimum Eligible Age

16 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanol GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

+1 877 822 9493 (UCB)

Locations

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15

Changsha, , China

Site Status

16

Changsha, , China

Site Status

1

Fuzhou, , China

Site Status

10

Guangzhou, , China

Site Status

5

Hangzhou, , China

Site Status

6

Hangzhou, , China

Site Status

7

Jinan, , China

Site Status

8

Jinan, , China

Site Status

13

Shanxi, , China

Site Status

14

Shanxi, , China

Site Status

12

Shenyang, , China

Site Status

2

Tianjin, , China

Site Status

17

Wenzhou, , China

Site Status

4

Wuxi, , China

Site Status

9

Xi'an, , China

Site Status

Countries

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China

Related Links

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Other Identifiers

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2014-004380-20

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

SP0986

Identifier Type: -

Identifier Source: org_study_id

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