ION US Post-Approval Study

NCT ID: NCT01422889

Last Updated: 2016-02-04

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-09-30

Study Completion Date

2015-02-28

Brief Summary

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The purpose of this study is to compile real-world clinical outcomes data for the ION™ Paclitaxel-Eluting Platinum Chromium Coronary Stent System in routine clinical practice.

Detailed Description

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The ION™ stent is the third-generation Boston Scientific (BSC) paclitaxel-eluting coronary stent. It is designed for improved performance specific to deliverability and radio-opacity while maintaining a similar drug release profile of the TAXUS Express and TAXUS Liberté stents. Following PMA approval from the FDA for the ION™ Paclitaxel-Eluting Platinum Chromium Coronary Stent System the ION US Post-Approval study will compile real-world clinical outcomes data for the ION™ Paclitaxel-Eluting Platinum Chromium Coronary Stent System in routine clinical practice. Post-approval studies of drug-eluting stents (DES) provide an opportunity to observe and assess patient outcomes and technology performance in a real-world setting.

Conditions

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Atherosclerosis Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ION Registry

The ION Registry population was designed to collect real world safety and clinical outcomes data. There were 1120 subjects were enrolled, however 9 subjects did not receive a study stent therefore 1111 subjects were eligible for follow up.

ION™ Coronary Stent System

Intervention Type DEVICE

This study is intended to evaluate the ION™ Paclitaxel-Eluting Platinum Chromium Coronary Stent System across a range of institutions and physician users to observe and assess subject outcomes and technology performance in a real-world setting.

Interventions

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ION™ Coronary Stent System

This study is intended to evaluate the ION™ Paclitaxel-Eluting Platinum Chromium Coronary Stent System across a range of institutions and physician users to observe and assess subject outcomes and technology performance in a real-world setting.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Consented subjects receiving one or more ION(TM)Coronary Stents

Exclusion Criteria

Subjects not clinically indicated to receive an ION (TM)Coronary Stent
Minimum Eligible Age

18 Years

Maximum Eligible Age

110 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Louis A Cannon, MD

Role: PRINCIPAL_INVESTIGATOR

Northern Michigan Hospital

Carey D Kimmelstiel, MD

Role: PRINCIPAL_INVESTIGATOR

Tufts Medical Center

Locations

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NEA Baptist Memorial Hospital

Jonesboro, Arkansas, United States

Site Status

St. Bernard's Medical Center

Jonesboro, Arkansas, United States

Site Status

Bakersfield Memorial Hospital

Bakersfield, California, United States

Site Status

Alvarado Hospital

San Diego, California, United States

Site Status

Northside Hospital and Heart Institute

St. Petersburg, Florida, United States

Site Status

University Community Hospital

Tampa, Florida, United States

Site Status

Redmond Regional Medical Center

Rome, Georgia, United States

Site Status

Kootenai Medical Center

Coeur d'Alene, Idaho, United States

Site Status

Krannert Institute of Cardiology

Indianapolis, Indiana, United States

Site Status

Indiana Heart Hospital

Indianapolis, Indiana, United States

Site Status

Iowa Heart Center

West Des Moines, Iowa, United States

Site Status

King's Daughters Medical Center - Kentucky Heart Inst

Ashland, Kentucky, United States

Site Status

Maine Medical Center

Portland, Maine, United States

Site Status

Union Memorial Hospital

Baltimore, Maryland, United States

Site Status

Tufts Medical Center

Boston, Massachusetts, United States

Site Status

Sparrow Health System - Sparrow Hospital

Lansing, Michigan, United States

Site Status

Northern Michigan Hospital

Petoskey, Michigan, United States

Site Status

Lakeland Hospitals at St. Joseph

Saint Joseph, Michigan, United States

Site Status

Memorial Hospital at Gulfport

Gulfport, Mississippi, United States

Site Status

Freeman West Hospital

Joplin, Missouri, United States

Site Status

Our Lady of Lourdes Medical Center

Haddon Heights, New Jersey, United States

Site Status

Jersey Shore University Medical Center

Sea Girt, New Jersey, United States

Site Status

St. Joseph's Hospital Health Center

Liverpool, New York, United States

Site Status

St. Elizabeth Medical Center

Utica, New York, United States

Site Status

Wake Medical Center

Raleigh, North Carolina, United States

Site Status

Ohio State University Medical Center

Columbus, Ohio, United States

Site Status

Riverside Methodist Hospital

Columbus, Ohio, United States

Site Status

Mercy St. Vincent Medical Center

Toledo, Ohio, United States

Site Status

Oklahoma Heart Hospital

Oklahoma City, Oklahoma, United States

Site Status

St. Mary Medical Center

Yardley, Pennsylvania, United States

Site Status

Sisters of Charity Providence Hospital

Columbia, South Carolina, United States

Site Status

Grand Strand Regional Medical Center

Myrtle Beach, South Carolina, United States

Site Status

Regional Hospital

Jackson, Tennessee, United States

Site Status

Centennial Medical Center

Nashville, Tennessee, United States

Site Status

Baylor Heart & Vascular Hospital

Dallas, Texas, United States

Site Status

CRSTI/Medical City Dallas

Dallas, Texas, United States

Site Status

Kingwood Medical Center Hospital

Kingwood, Texas, United States

Site Status

Methodist Texsan Hospital

San Antonio, Texas, United States

Site Status

Meriter Hospital, Inc.

Madison, Wisconsin, United States

Site Status

CaRE Foundation, Inc.

Wausau, Wisconsin, United States

Site Status

Countries

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United States

References

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Cannon L, Kimmelstiel CD, Kellett M, White A, Hill R, Grady T, Myers PR, Underwood P, Dawkins KD. One-year real-world outcomes following implantation of the ION paclitaxel-eluting platinum chromium coronary stent in routine clinical practice: Primary endpoint results of the ION U.S. post-approval registry [abstract]. J Am Coll Cardiol. 2013; 62 (18 SUPPL. 1): B58

Reference Type RESULT

Kimmelstiel CD, Cannon LA, Jobe RL, Stoler R, Pow T, Ganim R, Kayser R, Allocco DJ, Dawkins KD. Two-Year "Real-World" Outcomes Following Implantation of the ION™ Paclitaxel-Eluting Platinum Chromium Coronary Stent in Routine Clinical Practice: Results From the ION U.S. Post-Approval Registry. Presented at: The Transcatheter and Cardiovascular Therapeutics Annual Meeting 2014; Washington, D.C, USA. September 13 - 17, 2014.

Reference Type RESULT

Other Identifiers

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S2065

Identifier Type: -

Identifier Source: org_study_id

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