Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects

NCT ID: NCT01422668

Last Updated: 2011-08-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-03-31
• Study Completion Date: 2010-06-30

Brief Summary

The aim of this study was to evaluate the composition of Khalas, a very common type of dates used in the UAE and to determine the effects of drinking Arabic coffee on the results of GI tests in both healthy and diabetic subjects.

Detailed Description

Background:The consumption of dates along with coffee is a deeply rooted habit in many societies. This study was designed to determine the effect of coffee consumption on the glycemic index of a common variety of dates (Khalas) tested in healthy subjects and individuals with type 2 diabetes mellitus.

Methods:Composition analysis was carried out for Khalas dates (Tamer stage) and the weight of the dates flesh equivalent to 50 g of available carbohydrate was calculated. The study subjects were thirteen healthy volunteers with a mean (± SD) age of 40.2 ± 6.7 years and ten participants with type 2 diabetes mellitus (controlled on lifestyle measures and/or metformin) with a mean HbA1c (± SD) of 6.6 ± (0.7 %) and a mean age (± SD) of 40.8 ± 5.7 years. Each subject was tested on five separate days with 50 g of glucose (on 3 occasions) and 50 g equivalent of available carbohydrates from the dates without coffee (on one occasion) and with coffee (on another occasion). Capillary glucose was measured in the healthy subjects at 0, 15, 30, 45, 60, 90 and 120 min and for the diabetics at 0, 30, 60, 90, 120, 150 and 180 min. The glycemic indices were determined as ratios of the incremental areas under the response curves for the dates alone/with coffee compared to glucose. Statistical analyses were performed using Student's t-tests.

Conditions

Diabetes Mellitus

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Blinding Strategy: SINGLE

Study Groups

GI of Khalas dates

The Glycemic indices of the Khalas dates were measured for healthy and diabetic subjects.

Group Type: ACTIVE_COMPARATOR

Khalas dates

Intervention Type: OTHER

every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates

GI of the Khalas dates with Coffee

measuring the effect of 100 ml of coffee consumption on the GI of the Khalas dates among healthy and diabetic subjects.

Group Type: EXPERIMENTAL

Khalas dates

Intervention Type: OTHER

every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates

Interventions

Khalas dates

every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• required that those in the healthy group were healthy and in the diabetes group that their diabetes was controlled (HbA1c ≤8%) on diet with or without metformin

Exclusion Criteria

• morbid obesity (BMI > 40 kg/m2)
• pre diabetes
• pregnancy
• presence of gastroenterological disorders
• alimentary tract surgery
• a history of gastroenteritis in the prior six months
• any alcohol intake
• smoking
• taking any medications (except metformin)
• poorly controlled diabetes (HbA1c > 8%) and the presence of acute or chronic diseases

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

United Arab Emirates University

OTHER

Sponsor Role: lead

Responsible Party

Juma Alkaabi

Assistant Professor of Medicine, Faculty of Medicine and Health Sciences

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Juma M Alkaabi, MD

Role: PRINCIPAL_INVESTIGATOR

Assistant professor Internal Medicine Department FMHS UAE University

Bayan Al-Dabbag, PhD

Role: STUDY_CHAIR

FMHS UAE university

Hussein Saadi, MD

Role: STUDY_CHAIR

Professor of Medicine, FMHS UAE University

Salah Gariballa, MD

Role: STUDY_CHAIR

Professor of Medicine FMHS UAE University

Yasin Javed, Msc

Role: STUDY_CHAIR

FMHS UAE University

Locations

Faculty of Medicine and Health Sciences UAE University

Al Ain City, AB, United Arab Emirates

Countries

United Arab Emirates

Other Identifiers

UAEU: GI Dates Study

Identifier Type: -

Identifier Source: org_study_id