Metal on Metal Versus Metal on Highly Crossed Linked Polyethylene Sytem

NCT ID: NCT01422564

Last Updated: 2015-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2010-12-31

Brief Summary

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This trial will evaluate the 36mm or greater metal head on metal hip system and compare it to the 32mm or 28mm metal head on polyethylene (liner) hip system in patients receiving a primary cementless total hip replacement.

Detailed Description

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Conditions

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Osteoarthritis Avascular Necrosis Rheumatoid Arthritis Congenital Dysplasia of the Hip Ankylosing Spondylitis Post-traumatic; Arthrosis Injury of Hip and Thigh

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Metal on Metal

Metal on Metal articulation system

Group Type ACTIVE_COMPARATOR

Metal on Metal Hip System

Intervention Type DEVICE

Total hip arthroplasty with a metal on metal component system

HCLPC

THA using Highly Cross Linked Polyethylene cup System

Group Type ACTIVE_COMPARATOR

Highly Cross Linked Polyethylene cup System

Intervention Type DEVICE

Total hip arthroplasty with Highly Cross Linked Polyethylene cup System

Interventions

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Metal on Metal Hip System

Total hip arthroplasty with a metal on metal component system

Intervention Type DEVICE

Highly Cross Linked Polyethylene cup System

Total hip arthroplasty with Highly Cross Linked Polyethylene cup System

Intervention Type DEVICE

Other Intervention Names

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Depuy ASR Depuy Pinnacle Cup and Marathon liner

Eligibility Criteria

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Inclusion Criteria

* Male and non-pregnant female subjects 65 years of age or older
* Subjects undergoing cementless hip arthroplasty. If a press fit metal articulation acetabulum is not possible; the modular cup system will be utilized with screw fixation and a metal head of the greatest diameter deemed appropriate and safe for the patient will be utilized.(At the discretion of the surgeon). The cup in this situation may have a metal or poly articulation. The patient will be followed as an intent to treat (the patient will be evaluated and included in the group as randomized)
* Subjects with, but not limited to, original diagnoses of osteoarthritis, avascular necrosis, rheumatoid arthritis, congenital dysplasia of the hip, ankylosing spondylitis, posttraumatic arthritis, and traumatic injury to the hip joint.
* Subjects who are able and willing to understand the conditions of informed consent, to participate in the study according to the protocol for the length of the expected term of follow-up, and to follow their physician's directions.

Exclusion Criteria

* Subjects undergoing hip arthroplasty using a cemented femoral component and/or a bipolar prosthesis.
* Subjects with gross obesity, \>45% over ideal body weight for age and height. Refer to Appendix A, Obesity Table.
* Subjects with active infections.
* Subjects with malignancy in the area of the involved hip joint.
* Subjects with a neuromuscular deficit that interferes with the subject's ability to limit weight bearing or places an extreme load on the implant during the healing period.
* Subjects with a diagnosis of Fibromyalgia
* Female subjects who are pregnant or may be pregnant.
* Subjects whom, as judged by the surgeon, are not capable of understanding the informed consent or the requirements of the protocol, or are reasonably unlikely to be compliant with the prescribed postoperative routine and the follow-up evaluation schedule.
* Subjects who have a known sensitivity to device materials.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Health Network, Toronto

OTHER

Sponsor Role collaborator

Nova Scotia Health Authority

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ross K Leighton, MD

Role: PRINCIPAL_INVESTIGATOR

Nova Scotia Health Authority

Other Identifiers

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RL 006

Identifier Type: -

Identifier Source: org_study_id

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