Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
8100 participants
OBSERVATIONAL
2010-10-31
2014-12-31
Brief Summary
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Different blood tests are compared at the early stages of dengue fever onset in their ability to accurately and specifically detect children whose dengue will progress to severe disease.
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Detailed Description
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The study is intended to develop a prognostic algorithm for the early identification of severe dengue cases.
Routine demographic, haematological and biochemical laboratory markers will be utilized to derive a prognostic algorithm that is clinically-useful for guiding patient triage and interventions.
We hope to discover and evaluate new early biomarkers of severe dengue and will evaluate candidate host response molecules and virological markers for their prognostic value.
We further plan to understand the phylogeography of DENV in the super-urban setting of HCMC.
We will use genome scale sequencing of DENV together with geospatial information on the residential addresses of patients to better understand transmission dynamics in space and time in a high transmission super-urban district of HCMC and thereby identify opportunities for public health interventions.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Suspected dengue fever
Children aged 1-15 presenting at participating hospitals with symptoms of dengue fever
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Axillary temperature \>=37.5C
* Less than 72hrs of fever
* Resident in Ho Chi Minh City
* 1-15 yrs of age
* Accompanying family member or guardian has a mobile phone
* Written informed consent
Exclusion Criteria
* Any patient in who the attending physician believes another diagnosis is more likely.
1 Year
15 Years
ALL
No
Sponsors
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Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
OTHER
Children's Hospital Number 1, Ho Chi Minh City, Vietnam
OTHER
Number 2 Children's Hospital, Ho Chi Minh City
OTHER
Tien Giang Provincial Hospital, Tien Giang, Viet Nam
UNKNOWN
Red Cross Clinic Of District 8
OTHER
Oxford University Clinical Research Unit, Vietnam
OTHER
Responsible Party
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Principal Investigators
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Cameron Simmons, PhD
Role: PRINCIPAL_INVESTIGATOR
Oxford University Clinical Research Unit
Locations
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Hospital for Tropical Diseases
Ho Chi Minh City, Ho Chi Minh, Vietnam
Countries
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Related Links
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Oxford University Clinical Research Unit
Study details and Informed Consent Form
Other Identifiers
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13DX
Identifier Type: -
Identifier Source: org_study_id
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