Inspiratory Muscle Training in Pulmonary Hypertension

NCT ID: NCT01410279

Last Updated: 2011-08-05

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-12-31
• Study Completion Date: 2011-12-31

Brief Summary

The purpose of this study is evaluate the effect the inspiratory muscle training on the functional capacity of patients with pulmonary hypertension.

Detailed Description

Pulmonary hypertension (PH) is a syndrome, in the case of hemodynamic alteration of a number of diseases and processes, such as the progressive increase in pulmonary vascular resistance, right heart failure and early death. Frequently patients with PH have reduced functional capacity, quality of life and survival. It was demonstrated recently that patients with HP also have inspiratory muscle weakness, possibly further increase the fatigue and dyspnea during exercise. To meet this need, inspiratory muscle training can lead to significant improvement in respiratory muscle strength, exercise tolerance and dyspnea, thus resulting in reduction of discomfort during activities of daily living, increase in exercise capacity and improved quality of life in different situations.

Conditions

Pulmonary Hypertension

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Interventions

Inspiratory muscle training

The load is adjusted weekly in thirty percent of maximal inspiratory pressure of the subject.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Clinical diagnosis pulmonary hypertension
• World Health Organization (WHO) functional class II to IV
• inspiratory muscle weakness

Exclusion Criteria

• obesity
• chronic obstructive pulmonary disease
• orthopedic and neurological disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Associação Fundo de Incentivo à Pesquisa

OTHER

Sponsor Role: collaborator

Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

Sponsor Role: collaborator

Hospital de Clinicas de Porto Alegre

OTHER

Sponsor Role: lead

Responsible Party

UFCSPA

Principal Investigators

Pedro Dal'Lago

Role: PRINCIPAL_INVESTIGATOR

Hospital de Clínicas de Porto Alegre

Locations

Hospital de Clinica de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Site Status: RECRUITING

Countries

Brazil

Central Contacts

Pedro Dal'Lago

Role: CONTACT

pdallago@ufcspa.edu.br

55(51)3303-8796

Glória M Ferreira

Role: CONTACT

glomenz@yahoo.com.br

55(51)9284.0703

Facility Contacts

Pedro Dal'Lago

Role: primary

pdallago@ufcspa.edu.br

+55(51)3303-8796

Glória M Ferreira

Role: backup

glomenz@yahoo.com.br

+55(51)9284-0703

References

Dall'Ago P, Chiappa GR, Guths H, Stein R, Ribeiro JP. Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. J Am Coll Cardiol. 2006 Feb 21;47(4):757-63. doi: 10.1016/j.jacc.2005.09.052. Epub 2006 Jan 26.

Reference Type: RESULT

PMID: 16487841 (View on PubMed)

Mereles D, Ehlken N, Kreuscher S, Ghofrani S, Hoeper MM, Halank M, Meyer FJ, Karger G, Buss J, Juenger J, Holzapfel N, Opitz C, Winkler J, Herth FF, Wilkens H, Katus HA, Olschewski H, Grunig E. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation. 2006 Oct 3;114(14):1482-9. doi: 10.1161/CIRCULATIONAHA.106.618397. Epub 2006 Sep 18.

Reference Type: RESULT

PMID: 16982941 (View on PubMed)

Other Identifiers

09032

Identifier Type: -

Identifier Source: org_study_id